Role of fibroblast growth factor receptor 1 in the bone development and skeletal diseases

李福兵; 杜晓岚; 陈林

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Role of fibroblast growth factor receptor 1 in the bone development and skeletal diseases

Updated：2026-03-12

- Role of fibroblast growth factor receptor 1 in the bone development and skeletal diseases
- Role of fibroblast growth factor receptor 1 in the bone development and skeletal diseases
- 解放军医学杂志（英文版） 2007年第6期页码：376-384
- Affiliations：
  
  1. State Key Laboratory of Trauma Burns and Combined Injury
  2. Trauma Center
  3. Institute of Surgery Re-search.Duping Hospital.Third Military Medical University
  4. ,China
- Author bio：
- Funds：
  
  the National Key Basic Research and Devel opment Plan of China（973 Projects,2005CB522604）;the Research Project of Scientific Committee of Chongqing（2004BA5016）
- DOI：
  中图分类号： R681
- 纸质出版：2007
- Accepted：
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Role of fibroblast growth factor receptor 1 in the bone development and skeletal diseases[J]. 解放军医学杂志（英文版）, 2007,(6):376-384.

[1]李福兵,杜晓岚,陈林.Role of fibroblast growth factor receptor 1 in the bone development and skeletal diseases[J].Journal of Medical Colleges of PLA,2007(06):376-384.
Role of fibroblast growth factor receptor 1 in the bone development and skeletal diseases[J]. 解放军医学杂志（英文版）, 2007,(6):376-384. DOI：

[1]李福兵,杜晓岚,陈林.Role of fibroblast growth factor receptor 1 in the bone development and skeletal diseases[J].Journal of Medical Colleges of PLA,2007(06):376-384. DOI：

摘要

Abstract

<正>Accumulating data suggest that FGFs/FGFR1 plays essential roles in the bone development and human skeletal diseases.Conditional inactivation of fgfr1 caused different phenotypes displaying in different cells or specific organs and revealed some novel functions of FGFR1 in bone development.Fgfr1 mutation mainly induced 2 types of human skeletal diseases

craniosynostosis syndrome and dysplasias. Similar mutation of fgfr1 in mouse model just mimicked the phenotype that happened in human.These fa- cilitate the investigation on the underlying mechanism of the diseases.Here we mainly focused on the ad- vance of FGFR1 function in the bone development and its mutation caused skeletal diseases.

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