The effect of anastrozole on mRNA expression of oestrogen related gene in MCF-7 breast cancer cells

宋张骏; 吴怡; 马清涌

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The effect of anastrozole on mRNA expression of oestrogen related gene in MCF-7 breast cancer cells

Updated：2026-03-12

- The effect of anastrozole on mRNA expression of oestrogen related gene in MCF-7 breast cancer cells
- The effect of anastrozole on mRNA expression of oestrogen related gene in MCF-7 breast cancer cells
- 解放军医学杂志（英文版） 2006年第3期页码：178-181
- Affiliations：
  
  1. Department of Hepatobiliary Surgery First Hospital
  2. Xi’an Jiaotong University
  3. ,Xi’an,710004
  4. Department of Obstetrics and Gynaecology
  5. Fourth Hospital of Xi’an City
- Author bio：
- Funds：
- DOI：
  中图分类号： R737.9
- 纸质出版：2006
- Accepted：
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The effect of anastrozole on mRNA expression of oestrogen related gene in MCF-7 breast cancer cells[J]. 解放军医学杂志（英文版）, 2006,(3):178-181.

[1]宋张骏,吴怡,马清涌.The effect of anastrozole on mRNA expression of oestrogen related gene in MCF-7 breast cancer cells[J].Journal of Medical Colleges of PLA,2006(03):178-181.
The effect of anastrozole on mRNA expression of oestrogen related gene in MCF-7 breast cancer cells[J]. 解放军医学杂志（英文版）, 2006,(3):178-181. DOI：

[1]宋张骏,吴怡,马清涌.The effect of anastrozole on mRNA expression of oestrogen related gene in MCF-7 breast cancer cells[J].Journal of Medical Colleges of PLA,2006(03):178-181. DOI：

摘要

Abstract

<正>Objective: To look for additional markers of molecular biology response to anastrozole

a new aromatase inhibitor

on the growth and mRNA expression level of MCF-7 cell. Methods: We investigated the effect of anastrzole on growth and gene expression in the human breast cancer cell line MCF-7 and compared with the most widely used antiestrogen tamoxifen. We chose 4 genes to examine regulation of gene expression of estrogen regulated genes: PR A

PR B

ErbB-2 and cyclin D1. Results: Compared with the tamoxifen

a statistically significant growth inhibition was observed with anastrozole. The PR A

PR B and cyclin D1 mRNA level in anastrozole treated cells was sigificantly below the level in tamoxifen treated cells （P<0. 05）. They had agonistic effect on ErbB gene （P>0. 05）. Conclusion: The third generation of aromatase inhibitors anastrozole exert more inhibit function in some expression of estrogen regulated genes than tomoxifen in MCF-7 cell line.

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