Electrophysiological evidence of P2X2 receptor expression in the neurons of intracardiac and paratracheal ganglia

马蓓; 倪鑫; 韩红; BURNSTOCK Geoffrey

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Electrophysiological evidence of P2X2 receptor expression in the neurons of intracardiac and paratracheal ganglia

Updated：2026-03-12

- Electrophysiological evidence of P2X2 receptor expression in the neurons of intracardiac and paratracheal ganglia
- Electrophysiological evidence of P2X2 receptor expression in the neurons of intracardiac and paratracheal ganglia
- 解放军医学杂志（英文版） 2006年第3期页码：137-142
- Affiliations：
  
  1. Department of Physiology Second Military Medical University
  2. ,London
  3. Autonomic Neuroscience Institute
  4. Department of Anatomy and Developmental Biology
  5. Royal Free and University College Medical School
  6. Rowland Hill Street
  7. NW3 2PF
- Author bio：
- Funds：
  
  Supported by the National Natural Foundation of China （No. 30570597）
- DOI：
  中图分类号： R338
- 纸质出版：2006
- Accepted：
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Electrophysiological evidence of P2X2 receptor expression in the neurons of intracardiac and paratracheal ganglia[J]. 解放军医学杂志（英文版）, 2006,(3):137-142.

[1]马蓓,倪鑫,韩红,BURNSTOCK Geoffrey.Electrophysiological evidence of P2X2 receptor expression in the neurons of intracardiac and paratracheal ganglia[J].Journal of Medical Colleges of PLA,2006(03):137-142.
Electrophysiological evidence of P2X2 receptor expression in the neurons of intracardiac and paratracheal ganglia[J]. 解放军医学杂志（英文版）, 2006,(3):137-142. DOI：

[1]马蓓,倪鑫,韩红,BURNSTOCK Geoffrey.Electrophysiological evidence of P2X2 receptor expression in the neurons of intracardiac and paratracheal ganglia[J].Journal of Medical Colleges of PLA,2006(03):137-142. DOI：

摘要

Abstract

<正>Objective: To investigate the expression of P2X receptors on rat intracardiac and paratradieal ganglion neurons. Methods: For preparation of intracardiac neurons

hearts were excised

the atria were separated and the medial region containing intracardiac ganglia was isolated and cut into pieces. For preparation of paratracheal neurons

the tracheas were removed and the superficial membranous layer containing paratracheal ganglia was rapidly isolated. Intracardiac and paratracheal ganglion neurons were dissociated after digestion by collagenase and trypsin. Whole-cell patch clamp recording was used to identify the pharmacological properties of P2X receptors in cultured neurons. Results:Neurons from these two ganglia responded to ATP with a rapidly activating

sustained inward current.αβ-meATP failed to evoke any responses in paratracheal ganglion neurons while a few of intracardiac ganglion neurons responded toαβ-meATP with a tiny sustained inward current. ADP and UTP had no effect on intracardiac neurons. Lowering pH potentiated ATP responses in neurons from these two ganglia whereas increasing pH inhibited ATP responses. Co-application of Zn2+ potentiated ATP responses in intracardiac and paratracheal ganglion neurons. Conclusion: The receptor subtypes involved in intracardiac and paratracheal ganglia appear to be homomeric P2X2

while heteromeric P2X2/3 could not be completely excluded from intracardiac neurons.

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