<正>Objective: To retrospectively study the effects of epinephrine on blood pressure

heart rate as well as renal function in the patients with severe acute pancreatitis complicated with septic shock. Methods :Twenty-five patients with severe acute pancreatitis complicated with septic shock were divided into 3 groups according to the biggest infusing rate of epinephrine used

with the infusing rate of 0. 01-0. 05

0. 06-0. 10

>0. 10μg/kg·min in group A （n = 9）

B （n = 8） and C （n = 8）

respectively. Mean arterial blood pressure （MAP）

heart rate （HR）

urine output

blood urea nitrogen （BUN）

creatinine （CRE）

urine albumin （U-ALB） and urineβ2-microglubulin （Uβ2-MG） as well as APACHE III scoring were recorded in all the patients. Results: Before anti-shock therapy was given

hypotension

tachycardia

olig-uria as well as the abnormal levels of CRE

BUN

U-ALB

Uβ2-MG and APACHE III scoring occurred in all the 25 patients. With anti-shock therapy

MAP

HR

urine output and BUN

CRE in the patients from the 3 groups gradually returned to normal （P<0. 01 vs before anti-shock therapy）

and U-ALB

Uβ2-MG output and APACHE H scoring also restored but still remained abnormal （P<0. 01 vs before anti-shock therapy）. Conclusion: The first goal to treat the patients with severe acute pancreatitis complicated with septic shock should be restoring the organ blood supply. Based on volume resuscitation

epinephrine and other vasoactive drugs could be combined to maintain circulatory stability and also could benefit the restoration of the renal function.