Atorvastatin attenuates oxidative stress in Alzheimer’s disease

Cai Zhiyou Yan Yong Wang Yonglong Department of Neurology; the First Affiliated Hospital of Chongqing Medical University; Chongqing 400016; China

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Atorvastatin attenuates oxidative stress in Alzheimer’s disease

Updated：2026-03-12

- Atorvastatin attenuates oxidative stress in Alzheimer’s disease
- Atorvastatin attenuates oxidative stress in Alzheimer’s disease
- 解放军医学杂志（英文版） 2008年第1期页码：31-37
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the Doctoral Project of Chongqing Medical University（2006010068）.
- DOI：
  中图分类号： R749.1
- 纸质出版：2008
- Accepted：
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Atorvastatin attenuates oxidative stress in Alzheimer’s disease[J]. 解放军医学杂志（英文版）, 2008,(1):31-37.

[1].Atorvastatin attenuates oxidative stress in Alzheimer's disease[J].Journal of Medical Colleges of PLA,2008(01):31-37.
Atorvastatin attenuates oxidative stress in Alzheimer’s disease[J]. 解放军医学杂志（英文版）, 2008,(1):31-37. DOI：

[1].Atorvastatin attenuates oxidative stress in Alzheimer's disease[J].Journal of Medical Colleges of PLA,2008(01):31-37. DOI：

摘要

Abstract

<正>Objective:To investigate serum level of SOD

MDA

ox-LDL

AchE and Ach in AD

to study atorvastatin influence on serum level of SOD

MDA

ox-LDL

AchE and Ach in AD and its neuroprotection mechanisms.Methods Subjects were divided into:normal blood lipid level group with Alzheimer’s disease（A）

higher blood lipid level group with Alzheimer’s disease（AH）

normal blood lipid level Alzheimer’s disease group with atorvastatin treeatment（AT）

higher blood lipid level Alzheimer’s disease group with atorvastatin treeatment（AHT）.Ox-LDL was measured by enzyme linked immunosorbent assay;SOD

MDA

ox-LDL

AchE

Ach and blood lipid level in AD was measured by biochemistry.Results:The serum level of MDA

AchE in AH group after atorvastatin treatment is lower;The serum level of SOD

Ach in AH group is more increased than that of in A group;The serum level of ox-LDL in AH

A groups is lower than that of in A group;The dementia degree is lower after atorvastatin treatment.Conclusion:Atorvastatin can decrease serum level of MDA

AchE and ox-LDL

and increase that of SOD

Ach

and attenuate dementia symptom in AD

especially

with hyperlipemia.The hypothesis of atorvastatin neuroprotection is concluded that atorvastatin may restrain free radical reaction and retard oxidation in AD.

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