Inhibition of germ tube’s formation of Candida albicans by lactobacillus spp.

唐欢; 魏泓

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Inhibition of germ tube’s formation of Candida albicans by lactobacillus spp.

Updated：2026-03-12

- Inhibition of germ tube’s formation of Candida albicans by lactobacillus spp.
- Inhibition of germ tube’s formation of Candida albicans by lactobacillus spp.
- 解放军医学杂志（英文版） 2006年第5期页码：282-287
- Affiliations：
  
  1. Department of Animal Science College of Basic Medicine
  2. Third Military Medical University
  3. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号： Q93-3
- 纸质出版：2006
- Accepted：
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Inhibition of germ tube’s formation of Candida albicans by lactobacillus spp.[J]. 解放军医学杂志（英文版）, 2006,(5):282-287.

[1]唐欢,魏泓.Inhibition of germ tube's formation of Candida albicans by lactobacillus spp.[J].Journal of Medical Colleges of PLA,2006(05):282-287.
Inhibition of germ tube’s formation of Candida albicans by lactobacillus spp.[J]. 解放军医学杂志（英文版）, 2006,(5):282-287. DOI：

[1]唐欢,魏泓.Inhibition of germ tube's formation of Candida albicans by lactobacillus spp.[J].Journal of Medical Colleges of PLA,2006(05):282-287. DOI：

摘要

Abstract

<正>Objective:To investigate the effects of 6 strains of lactobacilli and their main culture metabolites on the morphogenesis of Candida albicans （C. albicans） so as to screen medicinal strains as antifungal agents. Methods: Spent culture supernatant （SC’S） at different culture time points

live lactobacilli

heat-killed bacteria and bacterial short-chain fatty acids （SCFA） with different molarities were incubated with C. albicans respectively. Crystal violet-based germ tube assay was used to detect the germination of C. al-bicans and the inhibitory efficiency of each addition was tested by germination rate. Results: SCS of lacto-bacillus spp. decreased the germination significantly and live bacteria of L. rhamnosus. GG

L. acidophilus 1.050103-12 as well as L. johnsonii JCM1022 could partially inhibit the conversion

however

all the heat-killed bacteria failed to control the germ tube formation. In addition

only butyric acid blocked the conversion of yeast to hypha among all the SCFA. Conclusion: The excellent fungistasis activities make L. rhamnosus. GG. L. acidophilus L050103 12 and L. johnsonii JCM1022 potential strains as antifungal drugs and the inhibition seems to have direct correlation to the metabolites.

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