<正>Objective:To evaluate the efficacy and safety of the treatment of chronic prostatitis/chronic pelvic pain syndrome （CP/CPPS）.Methods:The randomized controlled trials（RCTs） about the treatment for CP/CPPS all over the world were searched.MEDLINE（January 1966 to June 2007）.EMBASE （January 1988 to June 2007）

and 4 Chinese databases were electronically searched.The studies included in the refer- ences of eligible studies were additionally searched.Two reviewers independently screened the studies for eli gibility

evaluated the quality and extracted the data from the eligible studies

with confirmation by cross checking.Divergences of opinion were settled by discussion or consulted by the experts.Meta analysis was performed by using RevMan 4.2 software.Results:Twelve original studies involving 1003 participants met inclusion criteria.Compared with placebo

alpha blockers could improve the symptoms of CP/CPPSobvious- ly with WMD of NIH CPSI

total score and pain score were -4.10 （95%CI:-6.92 to -1.98） and -1.68 （95%CI:-2.64 to -0.82）.Antibiotics could not improve the symptoms obviously with WMD of NIH-CP- SI:total score and pain score were-2.71（95%CI:-4.78 to -0.64） and -0.86 （95%CI:2.07 to 0.36）.Flavoxate could not improve the NIH-CPSI total score obviously

but could relieve the pain

with WMDof NIH CPSI total score and pain score being -2.96（95%CI:-5.17 to -0.74） and -2.31 （95% CI:-4.05 to 0.03）.Prostat could improve the NIH-CPSI total score obviously

but could not relieve the pain

with WMD of NIH-CPSI total score and pain score being-7.60（95%CI:-9.97 to -5.23） and -2.02 （95%CI:-4.07 to 0.04）.Conclusion:Drug intervention could improve total symptoms of CP/CPPS in some degree

but no universally effective treatment is available that can prove significant lasting benefit for all the symptoms of CP/CPPS.Future RCT must use an appropriate sample size and optimal duration and fol- low up of participants.It is important to improvc the quality of internal original studies.