Heparanase antisense oligodeoxynucleotide inhibits angiogenesis and metastasis of human mammary carcinoma cell xenografts in nude mice

张友磊; 傅志仁; 丁国善; 张军; 沈茜; 王义

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Heparanase antisense oligodeoxynucleotide inhibits angiogenesis and metastasis of human mammary carcinoma cell xenografts in nude mice

Basic Medicine | Updated：2026-03-12

- Heparanase antisense oligodeoxynucleotide inhibits angiogenesis and metastasis of human mammary carcinoma cell xenografts in nude mice
- Heparanase antisense oligodeoxynucleotide inhibits angiogenesis and metastasis of human mammary carcinoma cell xenografts in nude mice
- 解放军医学杂志（英文版） 2007年第3期页码：143-148
- Affiliations：
  
  1. Eastern Hepatobiliary Surgery Hospital Second Military Medical University
  2. Liver Transplantation Center
  3. Changzheng Hospital
  4. Central Laboratory
  5. Changhai Hospital
  6. ,Shanghai,200433
- Author bio：
- Funds：
- DOI：
  中图分类号： R737.9
- 纸质出版：2007
- Accepted：
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Heparanase antisense oligodeoxynucleotide inhibits angiogenesis and metastasis of human mammary carcinoma cell xenografts in nude mice[J]. 解放军医学杂志（英文版）, 2007,(3):143-148.

[1]张友磊,傅志仁,丁国善,张军,沈茜,王义.Heparanase antisense oligodeoxynucleotide inhibits angiogenesis and metastasis of human mammary carcinoma cell xenografts in nude mice[J].Journal of Medical Colleges of PLA,2007(03):143-148.
Heparanase antisense oligodeoxynucleotide inhibits angiogenesis and metastasis of human mammary carcinoma cell xenografts in nude mice[J]. 解放军医学杂志（英文版）, 2007,(3):143-148. DOI：

[1]张友磊,傅志仁,丁国善,张军,沈茜,王义.Heparanase antisense oligodeoxynucleotide inhibits angiogenesis and metastasis of human mammary carcinoma cell xenografts in nude mice[J].Journal of Medical Colleges of PLA,2007(03):143-148. DOI：

摘要

Abstract

<正>Objective:To evaluate the inhibitory effect of heparanase antisense oligodeoxynucleotide （AS-ODN） on the angiogenesis and metastasis of human mammary carcinoma cell xenografts in nude mice. Methods:The AS-ODN complementary to the start codon region of heparanase mRNA and its control

scrambled nonsense oligodeoxynucleotide （NS-ODN） were designed and synthesized.A subcutaneous growth model and an acute hematogenous metastasis model of human mammary carcinoma were estab- lished in nude mice and were treated with ODNs.The heparanase expression in tumor was evaluated by RT-PCR and Western blot.The microvessel density （MVD） was measured by immunohistochemistry for factorⅧ.The tumor volume was calculated and lung metastatic nodules were counted.Results:The hep- aranase expression

MVD

tumor volume and lung metastatic nodules in AS-ODN treated group were sig- nificantly decreased compared with that in NS-ODN treated group and that in PBS group （P＜0.01）.Con- clusion:Heparanase AS-ODN has significant inhibitory effect on the angiogenesis and metastasis of human mammary carcinoma cell xenografts in nude mice.

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