Cx40 mRNA expression in crista terminalis and left atrium of patients with rheumatic heart disease associated chronic atrial fibrillation

Zhao Feng~(1; 2) Li Li~(1) Xu Zhiyun~1 Huang Xing~1 Zhou Yong~2 1 Department of Cardiothoracic Surgery.Changhai Hospital; Second Military Medical University; Shanghai 200433; China 2 Department of Cardiology; No.411 Hospital of PLA; Shanghai 200081; China

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Cx40 mRNA expression in crista terminalis and left atrium of patients with rheumatic heart disease associated chronic atrial fibrillation

Updated：2026-03-12

- Cx40 mRNA expression in crista terminalis and left atrium of patients with rheumatic heart disease associated chronic atrial fibrillation
- Cx40 mRNA expression in crista terminalis and left atrium of patients with rheumatic heart disease associated chronic atrial fibrillation
- 解放军医学杂志（英文版） 2008年第1期页码：26-30
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China（30070749）.
- DOI：
  中图分类号： R541.2
- 纸质出版：2008
- Accepted：
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Cx40 mRNA expression in crista terminalis and left atrium of patients with rheumatic heart disease associated chronic atrial fibrillation[J]. 解放军医学杂志（英文版）, 2008,(1):26-30.

[1].Cx40 mRNA expression in crista terminalis and left atrium of patients with rheumatic heart disease associated chronic atrial fibrillation[J].Journal of Medical Colleges of PLA,2008(01):26-30.
Cx40 mRNA expression in crista terminalis and left atrium of patients with rheumatic heart disease associated chronic atrial fibrillation[J]. 解放军医学杂志（英文版）, 2008,(1):26-30. DOI：

[1].Cx40 mRNA expression in crista terminalis and left atrium of patients with rheumatic heart disease associated chronic atrial fibrillation[J].Journal of Medical Colleges of PLA,2008(01):26-30. DOI：

摘要

Abstract

<正>Objectives:To explore possible mechanisms of connexin40（Cx40）remodeling by detecting Cx40 mRNA expression of the crista terminalis and left atrium（LA）in patients with rheumatic heart disease（RHD）associated chronic atrial fibrillation（AF）.Methods:Twenty patients were enrolled in this study

who underwent surgical operation for RHD-associated mitral disease

including 10 with sinus rhythms（rhythm group）and 10 with AF（AF group）.Another 6 patients with non-RHD sinus rhythms were divided into the control group.A small amount of myocardial tissue was cut from the crista terminalis and the LA posterior wall during the valvular replacement operation.Cx40 mRNA expression was assayed by real-time fluorescent quantitation polymerase chain reaction （RT-PCR）.Results:There was no significant difference in Cx40 mRNA expression in the crista terminalis and LA posterior wall between the 3 groups

and there was no significant difference in Cx40 mRNA expression between the crista terminalis and LA within each group.Conclusion:Based on the finding in previous studies that there existed evident remodeling of atrial Cx40 protein in patients with chronic RHD

the results of the present study suggest that the mechanism of Cx40 remodeling probably lies in the post transcriptional level.

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