HBV X-gene:A new serum marker for anti-HBV therapy monitoring

张伟; 李艳红; 朱少君; 巩丽; 王姝妹; 冯英明

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HBV X-gene:A new serum marker for anti-HBV therapy monitoring

Updated：2026-03-12

- HBV X-gene:A new serum marker for anti-HBV therapy monitoring
- HBV X-gene:A new serum marker for anti-HBV therapy monitoring
- 解放军医学杂志（英文版） 2007年第6期页码：370-372
- Affiliations：
  
  1. Department of Pathology Tangdu Hospital
  2. Fourth Military Medical University
  3. Department of Gynecology and Obstetrics
  4. ,China
- Author bio：
- Funds：
  
  the National Natural Science Foundation of China（No.30672013）
- DOI：
  中图分类号： R512.62
- 纸质出版：2007
- Accepted：
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HBV X-gene:A new serum marker for anti-HBV therapy monitoring[J]. 解放军医学杂志（英文版）, 2007,(6):370-372.

[1]张伟,李艳红,朱少君,巩丽,王姝妹,冯英明.HBV X-gene:A new serum marker for anti-HBV therapy monitoring[J].Journal of Medical Colleges of PLA,2007(06):370-372.
HBV X-gene:A new serum marker for anti-HBV therapy monitoring[J]. 解放军医学杂志（英文版）, 2007,(6):370-372. DOI：

[1]张伟,李艳红,朱少君,巩丽,王姝妹,冯英明.HBV X-gene:A new serum marker for anti-HBV therapy monitoring[J].Journal of Medical Colleges of PLA,2007(06):370-372. DOI：

摘要

Abstract

<正>Objective:To address HBV serum nucleic acid markers for stages without apparent replica- tion.Methods:DNA and RNA sequence segments from the X

C and pre C/C regions produced succes- sively during replication were used as targets for quantitative PCR and RT/PCR.Results:The assays con- firmed the preferential formation of intermediates blocked at early stages.They persisted as the only de- tectable type of serum HBV DNA even after one year of therapy.At reentry into viral replication due to e- mergence of drug resistant mutants

lamivudine resistance produced exclusively incomplete DNA minus strands

whereas the wild type virus immediately synthesized complete DNA minus strands.Conclusion: PCR assays used for monitoring complete suppression of HBV replication must target the X gene region.

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