Pathway and mechanism of oxidative stress in Alzheimer’s disease

蔡志友; 晏勇

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Pathway and mechanism of oxidative stress in Alzheimer’s disease

Updated：2026-03-12

- Pathway and mechanism of oxidative stress in Alzheimer’s disease
- Pathway and mechanism of oxidative stress in Alzheimer’s disease
- 解放军医学杂志（英文版） 2007年第5期页码：320-325
- Affiliations：
  
  1. Department of Neurology the First Affiliated Hospital of Chongqing Medical University
  2. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号： R749.16
- 纸质出版：2007
- Accepted：
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Pathway and mechanism of oxidative stress in Alzheimer’s disease[J]. 解放军医学杂志（英文版）, 2007,(5):320-325.

[1]蔡志友,晏勇.Pathway and mechanism of oxidative stress in Alzheimer's disease[J].Journal of Medical Colleges of PLA,2007(05):320-325+260.
Pathway and mechanism of oxidative stress in Alzheimer’s disease[J]. 解放军医学杂志（英文版）, 2007,(5):320-325. DOI：

[1]蔡志友,晏勇.Pathway and mechanism of oxidative stress in Alzheimer's disease[J].Journal of Medical Colleges of PLA,2007(05):320-325+260. DOI：

摘要

Abstract

Current hypotheses of pathogenesis of neuronal degeneration in Alzheimer’s disease （AD） have been proposed

including formation of free radicals

oxidative stress

mitochondrial dysfunction

inflammatory processes

genetic factors

environmental impact factors

apoptosis

and so on. Especially

oxidative stress plays an essential role in AD pathogenesis by the function of linking agent. Oxidative stress in AD mainly includes lipid peroxidation

protein oxidation and DNA oxidation. Lipid peroxidation plays a key role in the development and progression of AD. Protein oxidation is an important mechanism in AD. Oxidative damage to DNA may plays an important role in aging and AD.

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