<正>Objective:To observe the feasibility and safety of awake anesthesia for tumor excisions in pa- tients with brain tumors involving cerebral functional areas.Methods:Fifty patients with brain tumors in- volving cerebral functional areas

ASAⅠ-Ⅱgrade

were enrolled in this study.Propofol and remifentanil were used for total intravenous anesthesia

and a laryngeal mask airway（LMA）was inserted for the air- way opening and synchronized intermittent mandatory ventilation（SIMV）.At the surgeon’s request for an intraoperative wake-up test

the propofol infusion was stopped advance of 10-15 min

the remifentanil in- fusion rate was decreased to 0.050-0.075μg/kg from 0.10-0.20μg/kg per min for easing surgical pain. The LMA was removed until the patient awakened.The anesthesiologist then kept up an on-going neuro- logical examination.After that

anesthesia was re-deepened and LMA was re-inserted until the whole surgery was accomplished.Results:Forty-six of 50 patients（92%）were successfully awakened and 4 （8%）failed to complete the intraoperative wake-up test because of dyspnea

over-sedation

or severe hy pertension.No severe complications occurred during the whole process.Conclusions:During the awake anesthetic period

the intraoperative wake-up test combined with navigation

evoked potential and ultra- sound techniques can help surgeons excise maximumly and precisely the brain tumors near to or in the functional areas.