<正>Objective:To determine the changes of gastrointestinal migrating motor complex（MMC）during the early stage of cholesterol gallstone formation.Methods:Totally 45 healthy adult guinea pigs were randomly and equally divided into 3 groups

that is

normal control

group B（1% cholesterol diet for 2 weeks）and group C（1% cholesterol diet for 4 weeks）.Three pairs of silver electrodes were inserted into the gastric antrum

duodenum and jejunum of every animal respectively.Record of gastrointestinal MMC of these guinea pigs were recorded and analyzed. Gallbladder bile was taken to detect the formation of cholesterol gallstone.Results:There were only 29 guinea pigs living.The MMC cycle time and the duration of phaseⅡwere prolonged significantly and gradually compared with the control group（P<0.01）

but the duration of phaseⅢbecame significantly and gradually shorter.Conclusion: During the early stage of cholesterol gallstone formation

the MMC cycle time and the duration of phaseⅡare prolonged and the duration of phaseⅢis shortened