Characteristic of hyaluronic acid derivative films cross-linked by polyethylene glycol of low water content

Chen Jinghua~(1; 2) Chen Jingtao~2 Xu Zheng~2 Gu Qisheng~3 1 College of Publishing and Printing; University of Shanghai for Science and Technology; Shanghai 200093; China 2 College of Materials Science and Technology; Tongji University; Shanghai 200092; China 3 The Institute of Qisheng Biomaterial Technology; Shanghai 201106; China

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Characteristic of hyaluronic acid derivative films cross-linked by polyethylene glycol of low water content

Updated：2026-03-12

- Characteristic of hyaluronic acid derivative films cross-linked by polyethylene glycol of low water content
- Characteristic of hyaluronic acid derivative films cross-linked by polyethylene glycol of low water content
- 解放军医学杂志（英文版） 2008年第1期页码：15-19
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  中图分类号： R318.08
- 纸质出版：2008
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Characteristic of hyaluronic acid derivative films cross-linked by polyethylene glycol of low water content[J]. 解放军医学杂志（英文版）, 2008,(1):15-19.

[1].Characteristic of hyaluronic acid derivative films cross-linked by polyethylene glycol of low water content[J].Journal of Medical Colleges of PLA,2008(01):15-19.
Characteristic of hyaluronic acid derivative films cross-linked by polyethylene glycol of low water content[J]. 解放军医学杂志（英文版）, 2008,(1):15-19. DOI：

[1].Characteristic of hyaluronic acid derivative films cross-linked by polyethylene glycol of low water content[J].Journal of Medical Colleges of PLA,2008(01):15-19. DOI：

摘要

Abstract

<正>Objective:To test the characteristics of hyaluronic acid（HA）derivative cross-linked by polyethylene glycol films of low water content.Methods:The cross-linked HA film with 200μm thickness was got at atmospheric pressure at 25℃for 5 d.After dried

cross-linked films of 10 mm×10 mm were weighed and immersed in phosphate buffered saline （PBS pH 7.45）at 37℃for 24 h.Then the solution fraction and water content were estimated.Meanwhile

cross-linked HA derivative films were immersed in phosphate buffered saline（PBS:pH 7.45）at 37℃for determined time and then implanted subcutaneously in the back of white rats to test in vitro or in vivo degradation characteristic.Results and Conclusion:HA hydrogel cross-linked by polyethylene glycol with water content is as low as 60% and this kind of HA derivative has a slow degradation rate.

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