Objective: To evaluate the clinical efficacy and safety of patient-controlled intravenous analgesia （PCIA） with fentanyl for cystospasm after transurethral resection of the prostate. Methods: Sixty benign prostatic hyperplasia （BPH） patients scheduled for transurethral resection of the prostate （TURP） under general anesthesia with laryngeal mask airway （LMA） were randomly divided into groups F and S. Group F （n=30） received PCIA device with fentanyl 10 μg/kg+8 mg ondansetron

and Group S （n=30） received placebo （PCIA device with 8 mg ondansetron）. The visual analog scale （VAS） scores for pain were evaluated at 0

2

4

8

16

24

and 48 h by the same staff. And recorded were incidence of cystospasm

side effects

application of hemostatic

duration of drawing Foley catheter and continuous bladder irrigation

time of exhaust after operation

time of post-operative stay and cost of hospitalization. Results: The incidence of cystospasm in Group F was significantly lower than that in Group S in the 48 h after operation （P<0.05）

the VAS scores for pain in Group F was significantly lower than that in Group S within the 48 h after operation （P<0.01）. The time of exhaust after operation in Group F was significantly later than in Group S （P<0.05）. No significant difference was observed in applications of hemostatic

duration of drawing Foley catheter

duration of continuous bladder irrigation

time of post-operative stay and cost of hospitalization between the 2 groups. Conclusion: PCIA with fentanyl （10 μg/kg） relieves pain with little side effect and reduces cystospasm satisfactorily.