<正>Objective:To implant 80 mm-long artificial esophagi constructed of biomateriai in dogs

observe the perioperative survival rates and the incidence of postoperative complications

and study the mechanisms of postoperative healing.Methods:Specimens of the implanted esophagus

the"neo-esophagi"

were taken for histopathologic study 1

3

6

12

24 months after operation.Results:The incidence of anastomotic leakage after the artificial esophagus implantation was 3.33%.The perioperative survival rate was 96.67%.The incidence of postoperative stenosis in the"neo-esophagi"was 81.48%;the stenoses were treated by expanding with esophagoscopy and implanting a stent.Epithelization of the mucosa in the"neo-esophagi"was completed in 3 to 6 months after surgery Structures such as submucosal muscle layers

mucous glands

nerve fibers

capillaries

etc.were regenerated after 12 months

and then reconstruction of the fibrous connective tissue layer was completed.Conclusion:Implanting a biomaterial artificial esophagus accomplishes safe reconstruction of defects in the esophagus.Advanced cellular structure of"neo-esophagus"can be regenerated after 1 year.Postoperative stenosis

which is related to hyperplasia and retraction of scar tissue

is still the most common complications which limiting the clinical application of the artificial esophagus.