Toll-like receptors,a double-edged sword in immunity to malaria

Chen Jide1; He Ying2; Xu Wenyue1; Huang Fusheng1 1Department of Pathogenic Biology; College of Basic Medical Sciences; Third Military Medical University; Chongqing 400038; China 2Department of Clinical Laboratory; Chongqing Public Health Hospital Center; Chongqing 400036; China Received 23 October 2008; accepted 03 March 2009

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Toll-like receptors,a double-edged sword in immunity to malaria

Updated：2026-03-12

- Toll-like receptors,a double-edged sword in immunity to malaria
- Toll-like receptors,a double-edged sword in immunity to malaria
- 解放军医学杂志（英文版） 2009年24卷第2期页码：118-124
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  中图分类号： R392
- 纸质出版：2009
- Accepted：
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Toll-like receptors,a double-edged sword in immunity to malaria[J]. 解放军医学杂志（英文版）, 2009,24(2):118-124.

[1].Toll-like receptors,a double-edged sword in immunity to malaria[J].Journal of Medical Colleges of PLA,2009,24(02):118-124.
Toll-like receptors,a double-edged sword in immunity to malaria[J]. 解放军医学杂志（英文版）, 2009,24(2):118-124. DOI：

[1].Toll-like receptors,a double-edged sword in immunity to malaria[J].Journal of Medical Colleges of PLA,2009,24(02):118-124. DOI：

摘要

Abstract

Toll-like receptors（TLRs） are a central component of innate immune system and play a major role as the initiator of the innate immune responses to defend against bacteria

viruses

parasite and other pathogens.During malaria infection

TLRs signaling pathways are initialed with the recognition of Plasmodium glycosylphosphatidylinositols（GPI） and hemozoin as pathogen-associated molecular patterns（PAMPs）.And then

activation of TLRs signaling induces specific biological responses against malaria parasites invasion.However

TLRs are also involved in malaria pathogenesis and enhancement of immune tolerance and evasion for malaria infection.Moreover

malaria parasites regulate selectively TLRs expression on immune cells.Thus

these evidences indicated that TLRs have contrary roles on malaria infection.Understanding the complicated roles of TLRs on malaria infection will contribute us to design more effective anti-malaria drugs or vaccines.

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