Effect of amlodipine on apoptosis of human breast carcinoma MDA-MB-231 cells

Luo Lan1; Xu Xinghua1; Sun Wenjuan1; Dong Liying2 1Department of Pharmacology; College of Pharmacy; Key Laboratory of Biochemical Pharmacology of Chongqing; Chongqing Medical University; Chongqing 400016; China 2Department of Neurology; People’s Hospital of Qianxi County; Qianxi 064300; Hebei Province; China

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Effect of amlodipine on apoptosis of human breast carcinoma MDA-MB-231 cells

Updated：2026-03-12

- Effect of amlodipine on apoptosis of human breast carcinoma MDA-MB-231 cells
- Effect of amlodipine on apoptosis of human breast carcinoma MDA-MB-231 cells
- 解放军医学杂志（英文版） 2008年23卷第6期页码：358-363
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  中图分类号： R737.9
- 纸质出版：2008
- Accepted：
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Effect of amlodipine on apoptosis of human breast carcinoma MDA-MB-231 cells[J]. 解放军医学杂志（英文版）, 2008,23(6):358-363.

[1].Effect of amlodipine on apoptosis of human breast carcinoma MDA-MB-231 cells[J].Journal of Medical Colleges of PLA,2008,23(06):358-363.
Effect of amlodipine on apoptosis of human breast carcinoma MDA-MB-231 cells[J]. 解放军医学杂志（英文版）, 2008,23(6):358-363. DOI：

[1].Effect of amlodipine on apoptosis of human breast carcinoma MDA-MB-231 cells[J].Journal of Medical Colleges of PLA,2008,23(06):358-363. DOI：

摘要

Abstract

Objective: To elucidate the effects of amlodipine on the proliferation and apoptosis of human breast carcinoma MDA-MB-231 cells. Methods: Light microscopy was used to determine the effects of amlodipine on cell morphology; Flow cytometry was used to quantitate cells undergoing apoptosis; the expression of a cell cycle-related protein

proliferating cell nuclear antigen （PCNA） and an antiapoptosis protein

Bcl-2 were assessed by immunocytochemistry. Results: Amlodipine concentration of 8.25 μmol/L （1/2 of IC50） affected the morphology

decreased the expression of PCNA and Bcl-2 and induced apoptosis of human breast carcinoma MDA-MB-231 cells. Conclusion: The effect of amlodipine on the antiproliferation of human breast carcinoma MDA-MB-231 cells is related to inducement of apoptosis

and the decrease of the expression of Bcl-2 and PCNA may be the possible mechanism for proliferation inhibitory and inducement of apoptosis.

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