<正>Objective:To study the anti-fatigue effects of salidroside in mice.Methods:Totally 120 normal male Kunming mice were randomized into 5 groups （4 salidroside intervention groups and the control group） based on body weight. The control group was given distilled water and the 4 intervention groups were given various doses of salidroside （60

180

360

720 mg/kg） for 15 consecutive days

respectively.The levels of lactate

serum urea nitrogen

muscle and liver glycogen

the longest swimming time and hemoglobin were determined before and after swimming test.Results: Different doses of salidroside significantly lengthened the swimming time and increased the contents of hemoglobin and muscle and liver glycogen

while reducing that of lactate in blood significantly compared with control group

especially in the 180 mg/kg salidroside group.Conclusion:Salidroside has noticeable anti-fatigue effect on mice. These effects were dose-dependent

and the strongest effect on most biomarkers was seen with an intermediate dose.