TGF-β<sub>1</sub> inhibits connexin-43 expression in cultured smooth muscle cells of human bladder

Chi Qiang; Zhou Fenghai; Wang Yangmin Department of Urology; Lanzhou General Hospital of PLA; Lanzhou 730050; China

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TGF-β₁ inhibits connexin-43 expression in cultured smooth muscle cells of human bladder

Updated：2026-03-12

- TGF-β₁ inhibits connexin-43 expression in cultured smooth muscle cells of human bladder
- TGF-β₁ inhibits connexin-43 expression in cultured smooth muscle cells of human bladder
- 解放军医学杂志（英文版） 2009年24卷第5期页码：283-287
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  中图分类号： R694.5
- 纸质出版：2009
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TGF-β₁ inhibits connexin-43 expression in cultured smooth muscle cells of human bladder[J]. 解放军医学杂志（英文版）, 2009,24(5):283-287.

[1].TGF-β_1 inhibits connexin-43 expression in cultured smooth muscle cells of human bladder[J].Journal of Medical Colleges of PLA,2009,24(05):283-287.
TGF-β₁ inhibits connexin-43 expression in cultured smooth muscle cells of human bladder[J]. 解放军医学杂志（英文版）, 2009,24(5):283-287. DOI：

[1].TGF-β_1 inhibits connexin-43 expression in cultured smooth muscle cells of human bladder[J].Journal of Medical Colleges of PLA,2009,24(05):283-287. DOI：

摘要

Abstract

Objective: In this research

we studied the TGF-β1 effects on connexin-43 expression in cultured human bladder smooth muscle cells. Methods: Human bladder smooth muscle cells primary cultures

with bladder tissue obtained from patients undergoing cystectomy

were intervened by recombinant human TGF-β1. Connexin-43 expression in human bladder smooth muscle cells was then examined by Western blotting and immunocytochemistry. Results: Stimulation with TGF-β1 led to significant reduction of connexin-43 immunoreactivity and coupling （P<0.0001）. Connexin-43 protein expression was significantly downregulated （P<0.05）. Simultaneously

low phosphorylation species of connexin-43 were particularly affected. Conclusion: Our experiments demonstrated a significant downregulation of connexin-43 by TGF-β1 in cultured human bladder smooth muscle cells. These findings support the view that TGF-β1 is involved in the pathophysiology of urinary bladder dysfunction.

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TGF-β1 inhibits connexin-43 expression in cultured smooth muscle cells of human bladder

TGF-β1 inhibits connexin-43 expression in cultured smooth muscle cells of human bladder

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摘要

Abstract

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references

TGF-β₁ inhibits connexin-43 expression in cultured smooth muscle cells of human bladder

TGF-β₁ inhibits connexin-43 expression in cultured smooth muscle cells of human bladder