Reduction of natural regulatory T cells in thymomas accompanying myasthenia gravis and its possible association with Foxp3 and thymic stromal lymphopoietin

Wang Zhongkui; Wang Jinghua; Deng Benqiang; Ding Suju; Wu Tao Department of Neurology; Changhai Hospital; Second Military Medical University; Shanghai 200433; China

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Reduction of natural regulatory T cells in thymomas accompanying myasthenia gravis and its possible association with Foxp3 and thymic stromal lymphopoietin

Updated：2026-03-12

- Reduction of natural regulatory T cells in thymomas accompanying myasthenia gravis and its possible association with Foxp3 and thymic stromal lymphopoietin
- Reduction of natural regulatory T cells in thymomas accompanying myasthenia gravis and its possible association with Foxp3 and thymic stromal lymphopoietin
- 解放军医学杂志（英文版） 2009年24卷第1期页码：50-55
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  中图分类号： R736.3
- 纸质出版：2009
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Reduction of natural regulatory T cells in thymomas accompanying myasthenia gravis and its possible association with Foxp3 and thymic stromal lymphopoietin[J]. 解放军医学杂志（英文版）, 2009,24(1):50-55.

[1].Reduction of natural regulatory T cells in thymomas accompanying myasthenia gravis and its possible association with Foxp3 and thymic stromal lymphopoietin[J].Journal of Medical Colleges of PLA,2009,24(01):50-55.
Reduction of natural regulatory T cells in thymomas accompanying myasthenia gravis and its possible association with Foxp3 and thymic stromal lymphopoietin[J]. 解放军医学杂志（英文版）, 2009,24(1):50-55. DOI：

[1].Reduction of natural regulatory T cells in thymomas accompanying myasthenia gravis and its possible association with Foxp3 and thymic stromal lymphopoietin[J].Journal of Medical Colleges of PLA,2009,24(01):50-55. DOI：

摘要

Abstract

Objective: To investigate the expression of both thymic regulatory T cells （CD4+CD25+Foxp3+cells

Treg） and thymic stromal lymphopoietin （TSLP） in thymomas accompanying myasthenia gravis. Methods: We used immunohistochemistry and real-time reverse trancription polymerase chain reaction （real-time RT-PCR） techniques to determine Foxp3+ Treg counts and the expression levels of Foxp3 mRNA and TSLP mRNA in thymomas of 23 MG patients and thymuses of 4 healthy controls. Results: The CD4+ Foxp3+ nTreg （natural regulatory T cells） counts in thymomas were significantly lower than those in normal thymuses （P<0.01）

and the expression levels of Foxp3 mRNA and TSLP mRNA were also lower in thymomas（P<0.01）. Among the thymoma types

type B1 thymoma had the highest Foxp3+ nTreg count and standard values of Foxp3 mRNA and TSLP mRNA. There was a strong positive correlation between the mRNA transcriptional levels of Foxp3 and TSLP. Conclusion: The insufficient expression of Foxp3 in thymoma

which may be caused by decreased transcription of TSLP

may result in the reduction of Tregs and cause autoimmune disorders.

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