Possible effect of fluid shear stress on osteoclastogenesis

Tong Xiaoyu; Xia Yayi Orthopedic Department; Second Hospital; Lanzhou University; Lanzhou 730030; China

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Possible effect of fluid shear stress on osteoclastogenesis

Updated：2026-03-12

- Possible effect of fluid shear stress on osteoclastogenesis
- Possible effect of fluid shear stress on osteoclastogenesis
- 解放军医学杂志（英文版） 2010年25卷第2期页码：103-109
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  中图分类号： R580
- 纸质出版：2010
- Accepted：
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Possible effect of fluid shear stress on osteoclastogenesis[J]. 解放军医学杂志（英文版）, 2010,25(2):103-109.

[1].Possible effect of fluid shear stress on osteoclastogenesis[J].Journal of Medical Colleges of PLA,2010,25(02):103-109.
Possible effect of fluid shear stress on osteoclastogenesis[J]. 解放军医学杂志（英文版）, 2010,25(2):103-109. DOI：

[1].Possible effect of fluid shear stress on osteoclastogenesis[J].Journal of Medical Colleges of PLA,2010,25(02):103-109. DOI：

摘要

Abstract

Bone remodeling is performed under the joint action of osteoblasts and osteoclasts. Since the effect of osteoclasts has been gradually recognized on bone and joint diseases

targeted researches toward osteoclasts have become a hot research field. This article reviews the relevant medical literature concerning the possible effects of the fluid shear stress （FSS） on the osteoclastogenesis chiefly from the aspects of RANKL-RANK-OPG system

the macrophage colony-stimulating factor （M-CSF）

and calcitonin receptor （CTR）. On the basis of the changes of the expression of osteoclastic activities

it is suggested that FSS is a potent

important regulator of bone metabolism.

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