Prediction of HLA-A 2.1-restricted CTL epitopes from IGFBP7 antigen of lung carcinoma

Zhao Weipeng1; Long Haixia2; Zhu Bo1; Duan Yuzhong1; Chen Zhengtang1 1Cancer Research Center; Xinqiao Hospital; Third Military Medical University; Chongqing 400037; China 2School of Bioengineering; Chongqing Institute of Technology; Chongqing 400050; China

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Prediction of HLA-A 2.1-restricted CTL epitopes from IGFBP7 antigen of lung carcinoma

Updated：2026-03-12

- Prediction of HLA-A 2.1-restricted CTL epitopes from IGFBP7 antigen of lung carcinoma
- Prediction of HLA-A 2.1-restricted CTL epitopes from IGFBP7 antigen of lung carcinoma
- 解放军医学杂志（英文版） 2009年24卷第2期页码：63-68
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the Special fund of the National High Technology Research and Development Program of China （863 Program,2007AA02Z129）;the National Natural Science Foundation of China （30672076 and 30800506）
- DOI：
  中图分类号： R734.2
- 纸质出版：2009
- Accepted：
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Prediction of HLA-A 2.1-restricted CTL epitopes from IGFBP7 antigen of lung carcinoma[J]. 解放军医学杂志（英文版）, 2009,24(2):63-68.

[1].Prediction of HLA-A 2.1-restricted CTL epitopes from IGFBP7 antigen of lung carcinoma[J].Journal of Medical Colleges of PLA,2009,24(02):63-68.
Prediction of HLA-A 2.1-restricted CTL epitopes from IGFBP7 antigen of lung carcinoma[J]. 解放军医学杂志（英文版）, 2009,24(2):63-68. DOI：

[1].Prediction of HLA-A 2.1-restricted CTL epitopes from IGFBP7 antigen of lung carcinoma[J].Journal of Medical Colleges of PLA,2009,24(02):63-68. DOI：

摘要

Abstract

Objective:With the development of peptide-based cancer specific immunotherapy

the prediction of CTL epitopes from insulin-like growth factor-binding protein 7（IGFBP7） is very important for some research about tumor metastasis.Because HLA-A2.1-expressing individuals cover >50% in the population of China

we aimed at identifying IGFBP7-encoded peptide presented by HLA-A2.1.Methods:In our study

a HLA-A2.1 restricted CTL epitope was identified by using the following two-step procedure:（a） computer-based epitope prediction from the amino acid sequence of IGFBP7 antigen;（b） Validation with epitope molecular modeling.Results:We obtained four epitopes with high immunogenicity scores by all of the three algorithms

i.e.

BIMAS

SYFPEITHI and IMTECH.Each of the four candidates satisfied the criteria of the HLA-A2.1-restricted CTL epitopes in molecular modeling analysis.Conclusion:The combination of BIMAS

SYFPEITHI and IMTECH method can improve the prediction efficiency and accuracy.Due to this research herein

this four epitopes have potential value for further studied

also have potential application in peptide-mediated immunotherapy.These epitopes may be useful in the design of therapeutic peptide vaccine for lung carcinoma and as immunotherapeutic strategies against lung carcinoma after identified by immunology experiment.

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