Local administration of liposomal adriamycin inhibited proliferation of metastatic cells in axillary lymph nodes in rabbit breast cancer model

Li Xiaojun; Qin Hong; Yao Jia; Wang Jiansheng; Xian Yinsheng; Zhang Yunfeng; Ren Hong Department of Oncosurgery; First Affiliated Hospital; Medical School; Xi’an Jiaotong University; Xi’an 710061; China

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Local administration of liposomal adriamycin inhibited proliferation of metastatic cells in axillary lymph nodes in rabbit breast cancer model

Updated：2026-03-12

- Local administration of liposomal adriamycin inhibited proliferation of metastatic cells in axillary lymph nodes in rabbit breast cancer model
- Local administration of liposomal adriamycin inhibited proliferation of metastatic cells in axillary lymph nodes in rabbit breast cancer model
- 解放军医学杂志（英文版） 2009年24卷第3期页码：161-166
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  中图分类号： R737.9
- 纸质出版：2009
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Local administration of liposomal adriamycin inhibited proliferation of metastatic cells in axillary lymph nodes in rabbit breast cancer model[J]. 解放军医学杂志（英文版）, 2009,24(3):161-166.

[1].Local administration of liposomal adriamycin inhibited proliferation of metastatic cells in axillary lymph nodes in rabbit breast cancer model[J].Journal of Medical Colleges of PLA,2009,24(03):161-166.
Local administration of liposomal adriamycin inhibited proliferation of metastatic cells in axillary lymph nodes in rabbit breast cancer model[J]. 解放军医学杂志（英文版）, 2009,24(3):161-166. DOI：

[1].Local administration of liposomal adriamycin inhibited proliferation of metastatic cells in axillary lymph nodes in rabbit breast cancer model[J].Journal of Medical Colleges of PLA,2009,24(03):161-166. DOI：

摘要

Abstract

Objective:To assess the inhibitory effects of liposomal adriamycin（LADR） locally injected into mammary glands of VX2 tumor-bearing rabbits on proliferation of lymph nodal metastatic cells.Methods:Twenty-one VX2 tumor-bearing rabbits were randomly and equally divided into 3 groups.Rabbits were randomized to receive sham treatment（Group I）

subcutaneous LADR around tumor（Group II） and intravenous free adriamycin（Group III）

respectively.Breast tumor and axillary lymph nodes were harvested after 3 repeated treatment.Nodal sizes of both pre-and post-treatment were measured.Proliferating cell nuclear antigen（PCNA） mRNA in both tumor and lymph nodes were determined by RT-PCR.Results:The mean size of axillary lymph nodes in Group I

II and III increased by 3.70%

1.55% and 2.89%

respectively

with significant difference between Group III and I（P=0.004） and between Group II and III（P=0.002）.Relative expression values of PCNA mRNA in breast tumors of Group I

II and III were 0.486

0.513 and 0.396

respectively.For Group III

PCNA mRNA was significantly less expressed than that in Group I（P=0.023） and II（P=0.005）.Relative expression values of PCNA mRNA in axillary lymph nodes of Group I

II and III were 0.541

0.329 and 0.450

respectively.Compared with Group I

Group III showed a markedly decreased expression of PCNA（P=0.021）.The least level of PCNA mRNA was found in Group II

with a significant difference from that in Group III（P=0.004）.Conclusion:Local injection of LADR was an effective therapeutic regimen for lymphatic metastases from breast cancer

regardless of its little effect on primary tumor.

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