Analysis on blood glucose excursions in well-controlled patients with type 2 diabetes mellitus

Deng Wuquan1; Yu Qiongwu2; Wang Fuhua1; Ai Zhihua1; Chen Bing1 1Department of Endocrinology; Southwest Hospital; Third Military Medical University; Chongqing 400038; China 2Department of Ophthalmology; Southwest Hospital; Third Military Medical University; Chongqing 400038; China

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Analysis on blood glucose excursions in well-controlled patients with type 2 diabetes mellitus

Updated：2026-03-12

- Analysis on blood glucose excursions in well-controlled patients with type 2 diabetes mellitus
- Analysis on blood glucose excursions in well-controlled patients with type 2 diabetes mellitus
- 解放军医学杂志（英文版） 2009年24卷第2期页码：92-98
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the National “Eleventh Five-year Plan” for Major Scientific and Technological Research （2006BAI02B08）
- DOI：
  中图分类号： R587.1
- 纸质出版：2009
- Accepted：
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Analysis on blood glucose excursions in well-controlled patients with type 2 diabetes mellitus[J]. 解放军医学杂志（英文版）, 2009,24(2):92-98.

[1].Analysis on blood glucose excursions in well-controlled patients with type 2 diabetes mellitus[J].Journal of Medical Colleges of PLA,2009,24(02):92-98.
Analysis on blood glucose excursions in well-controlled patients with type 2 diabetes mellitus[J]. 解放军医学杂志（英文版）, 2009,24(2):92-98. DOI：

[1].Analysis on blood glucose excursions in well-controlled patients with type 2 diabetes mellitus[J].Journal of Medical Colleges of PLA,2009,24(02):92-98. DOI：

摘要

Abstract

Objective:To probe glycemic excursions in type 2 diabetic patients whose hemoglobin A1c（HbA1c） was kept ≤6.0%.Methods:Totally 36 cases with type 2 diabetes（T2DM） with HbA1c≤6.0% and 30 cases with normal glucose tolerance（NGT） from December 2005 to December 2007 in our department were subjected prospectively.Continuous glucose monitoring system（CGMS） was employed to record their continuous blood glucose level for 3 d.The blood glucose profiles including the mean blood glucose（MBG）

standard differentiation（SD）

mean amplitude of glycemic excursions（MAGE） and absolute means of daily differences（MODD） were analyzed.Results:T2DM group had obviously postprandial hyperglycemia

in about 2 h after meal

especially after breakfast.Fifty-two hypoglycemic episodes occurred during the monitoring period in T2DM groups

of which 73.1%（38 episodes） were absence of symptomatic hypoglycemia with the lowest value of blood glucose only 2.0 mmol/L.And 20 episodes took place during the day hours

while 32 episodes observed during the night hours.Compared with NGT groups

MAGE and MODD were all significantly higher in T2DM groups.MBG was significantly correlated with HbA1c in T2DM groups

but SD

MAGE

NGE and MODD were all independent of HbA1c.MAGE was independent of MODD.Conclusion:The amplitude of glycemic excursions is higher in normol-controlled T2DM groups than the NGT groups.Thus ideally glycemic control is not only to make HbA1c reach standard

but also to lessen glycemic excursions and reduce hypoglycemia episodes.

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