Adenovirus-mediated PTEN gene transfection suppresses growth and promotes chemosensitivity of endometrial carcinoma

Liu Yuhuan1; Wang Jiaqi2; Yang Peili3; Hu Jingjing2; Chen Chao2; Ji Mei1; Hui Ning1; Yu Chaoqin4; Cai Zailong2 1Department of Gynecology and Obstetrics; Changhai Hospital; Second Military Medical University; Shanghai 200433; China 2Clinical Research Center; Changhai Hospital; Second Military Medical University; Shanghai 200433; China 3Department of Gynecology and Obstetrics; Hospital of Beijing Municipal Corps of Chinese People’s Armed Police Force; Beijing 100027; China 4Department of Chinese Traditional Medicine; Changhai Hospital; Second Military Medical University; Shanghai 200433; China

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Adenovirus-mediated PTEN gene transfection suppresses growth and promotes chemosensitivity of endometrial carcinoma

Updated：2026-03-12

- Adenovirus-mediated PTEN gene transfection suppresses growth and promotes chemosensitivity of endometrial carcinoma
- Adenovirus-mediated PTEN gene transfection suppresses growth and promotes chemosensitivity of endometrial carcinoma
- 解放军医学杂志（英文版） 2010年25卷第4期页码：193-203
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China（30471676）;Shanghai Science and Technology Committee（04DZ19207-2）
- DOI：
  中图分类号： R737.33
- 纸质出版：2010
- Accepted：
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Adenovirus-mediated PTEN gene transfection suppresses growth and promotes chemosensitivity of endometrial carcinoma[J]. 解放军医学杂志（英文版）, 2010,25(4):193-203.

[1].Adenovirus-mediated PTEN gene transfection suppresses growth and promotes chemosensitivity of endometrial carcinoma[J].Journal of Medical Colleges of PLA,2010,25(04):193-203.
Adenovirus-mediated PTEN gene transfection suppresses growth and promotes chemosensitivity of endometrial carcinoma[J]. 解放军医学杂志（英文版）, 2010,25(4):193-203. DOI：

[1].Adenovirus-mediated PTEN gene transfection suppresses growth and promotes chemosensitivity of endometrial carcinoma[J].Journal of Medical Colleges of PLA,2010,25(04):193-203. DOI：

摘要

Abstract

Objective:To determine the potential of sustained transgene expression by intratumoral injection of Ad-PTEN in the nude mouse model of endometrial carcinoma.Methods and Results:We constructed recombinant adenovirus carrying the wild-type PTEN gene（Ad-PTEN）.RL95-2 cells

an endometrial carcinoma cell line lacking PTEN function

was infected with Ad-PTEN and showed increased expression of PTEN and chemosensitivity to doxorubicin

decreased proliferation rate

and elevated apoptosis and G0/G1 arrest.Furthermore

the tumorigenicity of these cells was also completely suppressed.These results indicated that gene therapy with Ad-PTEN could significantly inhibit the endometrial carcinoma xenografts growth in nude mice by intratumoral injection

induce apoptosis of tumor cells

and reduce expression of proliferating cell nuclear antigen（PCNA）.Immunohistochemistry analysis also showed that the expression of progesterone receptors（PR） in Ad-PTEN treated tumor cells were induced

while P-glycoproteins（P-gp） and estrogen receptors（ER） decreased significantly.Conclusion:PTEN may play an important role in the development of endometrial carcinoma.Our findings cast new lights for treatment of endometrial carcinoma.

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