Seven amino acid peptide mimic from HVR1 of HCV influences cytokine profile of immune cells

Song Chunhui; Chen Liming; Yang Bin; Chi Shuping; Cheng Yun Department of Liver Disease Research Center for Biology; No.302 Hospital of PLA; Beijing 100039; China

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Seven amino acid peptide mimic from HVR1 of HCV influences cytokine profile of immune cells

Updated：2026-03-12

- Seven amino acid peptide mimic from HVR1 of HCV influences cytokine profile of immune cells
- Seven amino acid peptide mimic from HVR1 of HCV influences cytokine profile of immune cells
- 解放军医学杂志（英文版） 2010年25卷第5期页码：257-266
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the National High Technology Research and Development Program of China（863 Program,No. 2006AA022494）
- DOI：
  中图分类号： R392
- 纸质出版：2010
- Accepted：
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Seven amino acid peptide mimic from HVR1 of HCV influences cytokine profile of immune cells[J]. 解放军医学杂志（英文版）, 2010,25(5):257-266.

[1].Seven amino acid peptide mimic from HVR1 of HCV influences cytokine profile of immune cells[J].Journal of Medical Colleges of PLA,2010,25(05):257-266.
Seven amino acid peptide mimic from HVR1 of HCV influences cytokine profile of immune cells[J]. 解放军医学杂志（英文版）, 2010,25(5):257-266. DOI：

[1].Seven amino acid peptide mimic from HVR1 of HCV influences cytokine profile of immune cells[J].Journal of Medical Colleges of PLA,2010,25(05):257-266. DOI：

摘要

Abstract

Objective:To investigate the actions of cytokine profile in the immune cells by a seven amino acid peptide mimic from HVR1 of HCV （GQTYTSG

named 7P）.Methods:The peripheral blood mononuclear cells （PBMCs） from 17 healthy blood donors were stimulated with 7P

and the cytokine levels in CD4+CD8-

CD4-CD8+ T cells

NKT cells were analyzed by the intracellular cytokine staining.Results:The frequency of cells which secreted interferon-γ （IFN-γ） was found to be significantly increased in all cells

interleukin-10（IL-10） was significantly increased in CD4+CD8-

CD4-CD8+ T cells but decreased in NK

NKT cells

and tumor necrosis factor-α （TNF-α） was decreased in CD4+CD8-

CD4-CD8+ but increased in NK cells.Conclusion:7P could induce a cytokine profile in different immune cells in vitro and there was some difference between the CD4+CD8-

CD4-CD8+ T cells which represented the adaptive immunity cells and NK

NKT cells which represented the innate immunity cells.This kind of variation of cytokine profile might contribute to anti-virus and anti-inflammatory immune reaction.

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