Genetically identified complete hydatidiform mole coexisting with a normal fetus following IVF-ET

Sui Jianzhong; Sun Xiaofang Guangzhou Key Laboratory of Reproductive and Genetics; the Third Affiliated Hospital of Guangzhou

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Genetically identified complete hydatidiform mole coexisting with a normal fetus following IVF-ET

Updated：2026-03-12

- Genetically identified complete hydatidiform mole coexisting with a normal fetus following IVF-ET
- Genetically identified complete hydatidiform mole coexisting with a normal fetus following IVF-ET
- 解放军医学杂志（英文版） 2009年24卷第6期页码：360-365
- Affiliations：
- Author bio：
- Funds：
  
  Supported by Production and Rresearch Projects of Guangdong Province （2007B090400140）
- DOI：
  中图分类号： R737.33
- 纸质出版：2009
- Accepted：
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Genetically identified complete hydatidiform mole coexisting with a normal fetus following IVF-ET[J]. 解放军医学杂志（英文版）, 2009,24(6):360-365.

[1].Genetically identified complete hydatidiform mole coexisting with a normal fetus following IVF-ET[J].Journal of Medical Colleges of PLA,2009,24(06):360-365.
Genetically identified complete hydatidiform mole coexisting with a normal fetus following IVF-ET[J]. 解放军医学杂志（英文版）, 2009,24(6):360-365. DOI：

[1].Genetically identified complete hydatidiform mole coexisting with a normal fetus following IVF-ET[J].Journal of Medical Colleges of PLA,2009,24(06):360-365. DOI：

摘要

Abstract

A complete hydatidiform mole coexisting with a fetus following in vitro fertilization and embryo transfer （IVF-ET） is a rare event. The diagnosis is often not easy because of the morphological similarity to a partial mole

but important to the treatment. We present a recent case in which STR polymorphism analysis clearly revealed a different genetic origin for the fetal and molar parts. STR polymorphisms on 15 variable number tandem repeat loci and a gender-determination locus

which were detected by polymerase chain reaction

indicating that the cord/placenta and molar tissue were parental and androgenous

respectively. During follow-up

the patient developed persistent gestational trophoblastic tumor （GTT） which was successfully treated with chemotherapy. In this case

STR polymorphism analysis exactly diagnosed a twin pregnancy consisting of a complete hydatidiform mole and a fetus.

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