A single nucleotide polymorphism in XRCC4 gene is associated with reduced colorectal cancer susceptibility in female

Zhang Zhongheng1; Hu Weiling2 1Jinhua Central Hospital; Jinhua 321000; China 2Sir Run Run Shaw Hospital; Hangzhou 310016; China

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A single nucleotide polymorphism in XRCC4 gene is associated with reduced colorectal cancer susceptibility in female

Updated：2026-03-12

- A single nucleotide polymorphism in XRCC4 gene is associated with reduced colorectal cancer susceptibility in female
- A single nucleotide polymorphism in XRCC4 gene is associated with reduced colorectal cancer susceptibility in female
- 解放军医学杂志（英文版） 2011年26卷第2期页码：85-93
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  中图分类号： R735.34
- 纸质出版：2011
- Accepted：
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A single nucleotide polymorphism in XRCC4 gene is associated with reduced colorectal cancer susceptibility in female[J]. 解放军医学杂志（英文版）, 2011,26(2):85-93.

[1].A single nucleotide polymorphism in XRCC4 gene is associated with reduced colorectal cancer susceptibility in female[J].Journal of Medical Colleges of PLA,2011,26(02):85-93.
A single nucleotide polymorphism in XRCC4 gene is associated with reduced colorectal cancer susceptibility in female[J]. 解放军医学杂志（英文版）, 2011,26(2):85-93. DOI：

[1].A single nucleotide polymorphism in XRCC4 gene is associated with reduced colorectal cancer susceptibility in female[J].Journal of Medical Colleges of PLA,2011,26(02):85-93. DOI：

摘要

Abstract

Objective:To investigate the association of XRCC4 polymorphic variants at G-1394T（rs6869366） with colorectal cancer susceptibility.Methods:In this hospital-based case-control study

the association of XRCC4 polymorphism with colorectal cancer risk in Chinese population was investigated.In total

171 patients with colorectal cancer and 171 healthy individuals matched for age and gender were selected.The genomic DNAs of the patients and controls were extracted from peripheral blood and the 300 bp target DNA was amplified with Polymerase Chain Reaction.The products were then digested with restriction endonuclease HincII

followed by agarose electrophoresis to identify the genotype.Results:We found a significant difference in the frequency of the XRCC4 G-1394T genotype between the colorectal cancer and control groups in female（1/127 vs 8/122

P<0.05）.Those with G/T at XRCC4 G-1394T showed a decreased risk of colorectal cancer susceptibility compared with those with T/T（OR 0.113

95%CI 0.014-0.932）.However

in overall population or in male

there was no significant difference of the distribution between the colorectal cancer and control groups.Conclusion:Our findings suggested that the G allele of XRCC4 G-1394T were associated with decreased risk of colorectal cancer susceptibility in female.

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