Effects of docetaxel,oxaliplatin and their combination on HeLa strain of cervical cancer

Zou Yuliang; Gou Wenli; Pei Meili; Xiao Jinghua; Liu Xiaolian Department of Gynaecology and Obstetrics; First Affiliated Hospital; Medical College; Xi’an Jiaotong University; Xi’an 710061; China

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Effects of docetaxel,oxaliplatin and their combination on HeLa strain of cervical cancer

Updated：2026-03-12

- Effects of docetaxel,oxaliplatin and their combination on HeLa strain of cervical cancer
- Effects of docetaxel,oxaliplatin and their combination on HeLa strain of cervical cancer
- 解放军医学杂志（英文版） 2010年25卷第4期页码：204-211
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  中图分类号： R737.33
- 纸质出版：2010
- Accepted：
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Effects of docetaxel,oxaliplatin and their combination on HeLa strain of cervical cancer[J]. 解放军医学杂志（英文版）, 2010,25(4):204-211.

[1].Effects of docetaxel,oxaliplatin and their combination on HeLa strain of cervical cancer[J].Journal of Medical Colleges of PLA,2010,25(04):204-211.
Effects of docetaxel,oxaliplatin and their combination on HeLa strain of cervical cancer[J]. 解放军医学杂志（英文版）, 2010,25(4):204-211. DOI：

[1].Effects of docetaxel,oxaliplatin and their combination on HeLa strain of cervical cancer[J].Journal of Medical Colleges of PLA,2010,25(04):204-211. DOI：

摘要

Abstract

Objective:To study the inhibitory effect of docetaxel（DOC）

oxaliplatin（OXA） and their combination on proliferation of cervical cancer line HeLa.Methods:Cell morphological changes were observed by inverted phase contrast microscope

cell inhibition rates in different groups were examined by MTT

and cell cycle and apoptosis rates were determined by flow cytometry（FCM）.Results:DOC and OXA inhibited the proliferation of cervical cancer cell line HeLa in a dose-dependent

and combination of the two drugs had an enhanced inhibitory effect;the apoptosis rate was also significantly increased when the two drugs were used in combination.Conclusion:DOC and OXA can synergistically inhibit the proliferation of cervical cancer cell line HeLa

which indicates that combination of the two drugs might has a promising future for clinical treatment of cervical cancer.

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