Objective:To evaluate the efficacy of entecavir and adefovir dipivoxil on HBeAg-positive nucleos（t）ide-naive patients with chronic hepatitis B with the method of Meta analysis.Methods:We searched PUBMED

EMBASE

CNKI （China National Knowledge Infrastructure）

the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews with reference to all data documented before May 2010.The dosage of entecavir and adefovir dipivoxil was 0.5 mg/d and 10 mg/d

respectively.Heterogeneity was examined by Chi-square test

the relative risk calculated and forest plot drawn.Rates of undetected serum HBV DNA

serum alanine aminotransferase （ALT） normalization

HBeAg clearance

HBeAg seroconversion and adverse effect occurrence were analyzed.Results:Six articles were included

which fit well in with this study.Meta analysis showed that the rate of undetected serum HBV DNA（P=0.000 2 at week 12

P=0.002 at week 48）and that of serum ALT normalization（P=0.04 at week 12

P=0.008 at week 48）in the entecavir group were higher than those in the adefovir dipivoxil group.However

no statistic significance existed between the two groups in the rate of HBeAg clearance （P=0.17）

the rate of HBeAg seroconversion（P=0.53）or the rate of adverse effect occurrence（P=0.92）at week 48.Conclusion:Entecavir was superior to adefovir dipivoxil in decreasing serum HBV DNA and normalizing serum ALT in the HBeAg-positive nucleos（t）ide-naive patients with chronic hepatitis B.