Effects of nerve growth factor on delayed afterdepolarization and triggered activity in the infarcted ventricle of rabbit model

Gao Yuling; Liu Yuqi; Lan Yunfeng; Wen Yi; Fang Zhou; Gao Jinliao; Wang Xueping; Wang Hongjuan; Li Yang Institute of Geriatric Cardiology; Chinese PLA General Hospital; Beijing 100853; China

Your Location：

Home >

Browse articles >

Effects of nerve growth factor on delayed afterdepolarization and triggered activity in the infarcted ventricle of rabbit model

Updated：2026-03-12

- Effects of nerve growth factor on delayed afterdepolarization and triggered activity in the infarcted ventricle of rabbit model
- Effects of nerve growth factor on delayed afterdepolarization and triggered activity in the infarcted ventricle of rabbit model
- 解放军医学杂志（英文版） 2011年26卷第1期页码：13-20
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the General Program of National Natural Science of China（30770901）
- DOI：
  中图分类号： R542.22
- 纸质出版：2011
- Accepted：
Scan QR Code
Effects of nerve growth factor on delayed afterdepolarization and triggered activity in the infarcted ventricle of rabbit model[J]. 解放军医学杂志（英文版）, 2011,26(1):13-20.

[1].Effects of nerve growth factor on delayed afterdepolarization and triggered activity in the infarcted ventricle of rabbit model[J].Journal of Medical Colleges of PLA,2011,26(01):13-20.
Effects of nerve growth factor on delayed afterdepolarization and triggered activity in the infarcted ventricle of rabbit model[J]. 解放军医学杂志（英文版）, 2011,26(1):13-20. DOI：

[1].Effects of nerve growth factor on delayed afterdepolarization and triggered activity in the infarcted ventricle of rabbit model[J].Journal of Medical Colleges of PLA,2011,26(01):13-20. DOI：

摘要

Abstract

正

The noninfarcted myocardium underwent significant electrophysiological remodelling as part of the healed myocardial infarction remodelling.This study aimed at investigating the effects of nervous growth factor（NGF） on delayed afterdepolarizations（DADs） and triggered activity（TA） of the noninfarcted myocardium in the myocardial infarcted rabbit model.Rabbits with the left anterior descending coronary artery occlusion were prepared and recovered for 8 weeks（HMI group

n=9）.Other rabbits with myocardial infarction were infused NGF to the left stellate ganglion （HMI+NGF group

400 U/day for 8 weeks

n=8）.Myocytes were isolated from regions of the noninfarcted left ventricular free wall.Action potentials and ion currents were recorded with whole-cell patch clamp.The results showed that more DADs and TA events of HMI+NGF myocytes than that of HMI and Ctrl group.I

and 7

Ca-L

of NGF+HMI myocytes were increased significantly compared with HMI and Ctrl cells

which contributed to DADs-related triggered arrhythmia.Comparing with HMI and Ctrl myocytes

significant prolongations of APD

and APD

in HMI+NGF myocytes were found.The results indicated the electrophysiological change of HMI myocytes with NGF infusion.It suggested that more events of DADs and TA in HMI myocytes with NGF treatment.The underlying mechanism may be involved in the increase of I

and I

Ca-L

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据