Prunella vulgaris L. extract improves cellular immunity in MDR-TB challenged rats

Lu Jun 1; Qin Rui 1; Ye Song 1; Yang Mei 2 1 Medical College; Anhui University of Science & Technology; Huainan 232001; China 2 Department of Clinical Laboratory; Huainan Chaoyang Hospital; Huainan 232001; China

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Prunella vulgaris L. extract improves cellular immunity in MDR-TB challenged rats

Updated：2026-03-12

- Prunella vulgaris L. extract improves cellular immunity in MDR-TB challenged rats
- Prunella vulgaris L. extract improves cellular immunity in MDR-TB challenged rats
- 解放军医学杂志（英文版） 2011年26卷第4期页码：230-237
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the Natural Science Foundation for Universities in Anhui Province （KJ2010A087 and KJ2008A152）
- DOI：
  中图分类号： R285.5
- 纸质出版：2011
- Accepted：
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Prunella vulgaris L. extract improves cellular immunity in MDR-TB challenged rats[J]. 解放军医学杂志（英文版）, 2011,26(4):230-237.

[1].Prunella vulgaris L. extract improves cellular immunity in MDR-TB challenged rats[J].Journal of Medical Colleges of PLA,2011,26(04):230-237.
Prunella vulgaris L. extract improves cellular immunity in MDR-TB challenged rats[J]. 解放军医学杂志（英文版）, 2011,26(4):230-237. DOI：

[1].Prunella vulgaris L. extract improves cellular immunity in MDR-TB challenged rats[J].Journal of Medical Colleges of PLA,2011,26(04):230-237. DOI：

摘要

Abstract

Objective: To study the effect of the extract of Prunella vulgaris L. on multiple drugs resistant bacillus tuberculosis （MDR-TB）. Methods: Experimental animal model in rats was induced by MDR-TB. Normal group

model group and Prunella vulgaris L. group were set up. The contents of IFN-γ

IL-4

IL-10 and IL-12 were examined by ELISA. Their genome mRNAs were extracted

the target genes were amplified by PCR. RT-PCR was used to detect the mRNA levels of them. Results: The content of IFN-γ of the extract of Prunella vulgaris L. group was 1.98±0.67 pg/ml

IL-4 was 6.47±1.46 pg/ml

IL-10 was 12.13±3.43 pg/ml and IL-12 was 3.02±0.86 pg/ml. Compared with the model group

Prunella vulgaris L. group was notable difference in serum IFN-γ

IL-12 and IL-10 （P<0.05）. The mRNA levels of IFN-γ

IL-12 increased and IL-10 decreased obviously

the differences were quite significant （P<0.05）

but IL-4 had no obvious change. Conclusion: The extract of Prunella vulgaris L. can enhance the cellar immunological function in rats from up-regulation of the level of genetic transcription

accordingly provide the theory basis of healing of tuberculosis with it.

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