A novel vWF A3-GPI modified EPCs to enhance its adhesion ability to collegen

Tan Hu; Song Yaoming; Jin Jun; Zhao Xiaohui; Huang Lan Department of Cardiovascular Diseases; Xinqiao Hospital; Third Military Medical University; Chongqing 400037; China

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A novel vWF A3-GPI modified EPCs to enhance its adhesion ability to collegen

Updated：2026-03-12

- A novel vWF A3-GPI modified EPCs to enhance its adhesion ability to collegen
- A novel vWF A3-GPI modified EPCs to enhance its adhesion ability to collegen
- 解放军医学杂志（英文版） 2011年26卷第4期页码：191-203
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China（30800479）
- DOI：
  中图分类号： R363
- 纸质出版：2011
- Accepted：
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A novel vWF A3-GPI modified EPCs to enhance its adhesion ability to collegen[J]. 解放军医学杂志（英文版）, 2011,26(4):191-203.

[1].A novel vWF A3-GPI modified EPCs to enhance its adhesion ability to collegen[J].Journal of Medical Colleges of PLA,2011,26(04):191-203.
A novel vWF A3-GPI modified EPCs to enhance its adhesion ability to collegen[J]. 解放军医学杂志（英文版）, 2011,26(4):191-203. DOI：

[1].A novel vWF A3-GPI modified EPCs to enhance its adhesion ability to collegen[J].Journal of Medical Colleges of PLA,2011,26(04):191-203. DOI：

摘要

Abstract

Objective:To gain purified recombination protein rGPI-vWF A3 which can guide endothelial progenitor cells （EPCs） gathering to the internal surface of the injured vessels theoretically and analyze its bioactivity in vitro. Methods: The plasmid vector of vWF A3 fusion protein which contained GPI structure was constructed and recombination protein rGPI-vWF A3 was expressed and its bioactivity was analyzed by ELISA and FCM. Results: Fusion protein vWF A3-GPI was expressed and purified by immunoaffinity chromatography and it could stably anchored on the surface of EPCs and showed its biological activities of collagen conjunction. Conclusion: These findings represent a novel strategy in EPC transplantation treatment for vessel injury.

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