Farnesoid X receptor expression is reduced in human hepatocellular carcinoma

Zhang Wenyu1; Chen Ping2; Zhao Yuanyin3; Lou Guiyu3 1Department of Endocrinology; People’s Hospital of Zhengzhou; Zhengzhou 450003; China 2Department of Hepatobiliary Surgery; Daping Hospital; Institute of Surgery Research; Third Military Medical University; Chongqing 400042; China 3Department of Biochemistry; College of Basic Medical Sciences; Third Military Medical University; Chongqing 400038; China

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Farnesoid X receptor expression is reduced in human hepatocellular carcinoma

Updated：2026-03-12

- Farnesoid X receptor expression is reduced in human hepatocellular carcinoma
- Farnesoid X receptor expression is reduced in human hepatocellular carcinoma
- 解放军医学杂志（英文版） 2012年27卷第1期页码：1-9
- Affiliations：
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China（30600299）
- DOI：
  中图分类号： R735.7
- 纸质出版：2012
- Accepted：
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Farnesoid X receptor expression is reduced in human hepatocellular carcinoma[J]. 解放军医学杂志（英文版）, 2012,27(1):1-9.

[1].Farnesoid X receptor expression is reduced in human hepatocellular carcinoma[J].Journal of Medical Colleges of PLA,2012,27(01):1-9.
Farnesoid X receptor expression is reduced in human hepatocellular carcinoma[J]. 解放军医学杂志（英文版）, 2012,27(1):1-9. DOI：

[1].Farnesoid X receptor expression is reduced in human hepatocellular carcinoma[J].Journal of Medical Colleges of PLA,2012,27(01):1-9. DOI：

摘要

Abstract

Farnesoid X receptor （FXR

NR1H4） is a member of nuclear hormone receptor superfamily. Previously studies showed that FXR-/- mice spontaneously developed liver tumors when they aged

however

the relevance of which to human hepatocellular carcinoma （HCC） is unclear. The aim of this study is to observe whether FXR expression is also downregulated in HCC and discuss the mechanism of the reduced FXR expression in HCC. Expression of FXR and small heterodimer partner （SHP） was measured by real-time PCR and immunohistochemical technique. Effect of pro-inflammatory cytokines on expression of FXR and its promoter activity were determined in primary hepatocytes or HepG2 and Huh7 cell lines. Our results showed that expression of FXR and its target gene SHP in human HCC was strongly downregulated compared to the normal liver tissues. In addition

pro-inflammatory cytokines were able to decrease FXR expression by inhibiting the FXR promoter activity. In conclusion this work demonstrates FXR expression is strongly downregulated in human HCC

which may be caused by decreased FXR promoter activity

suggesting a potential role of FXR in human HCC development.

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