Effect of remifentanil on toll-like receptor 4, NF-κB and IL-6 in rabbit myocardial ischemia/reperfusion model

Wang Wei 1; Tian Fuhong 2; Zhao Xinjing 1; Jing Guixia 1 1Department of Anesthesiology; First Affiliated Hospital; Medical School of Xi’an Jiaotong University; Xi’an 710061; China 2Department of Anesthesiology; Hancheng Mining Bureau General Hospital; Weinan 715401; China

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Effect of remifentanil on toll-like receptor 4, NF-κB and IL-6 in rabbit myocardial ischemia/reperfusion model

Updated：2026-03-12

- Effect of remifentanil on toll-like receptor 4, NF-κB and IL-6 in rabbit myocardial ischemia/reperfusion model
- Effect of remifentanil on toll-like receptor 4, NF-κB and IL-6 in rabbit myocardial ischemia/reperfusion model
- 解放军医学杂志（英文版） 2012年27卷第3期页码：134-142
- Affiliations：
- Author bio：
- Funds：
  
  Supported by Shaanxi Provincial Scientific and Technological Research Projects （2008K13-02）
- DOI：
  中图分类号： R363
- 纸质出版：2012
- Accepted：
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Effect of remifentanil on toll-like receptor 4, NF-κB and IL-6 in rabbit myocardial ischemia/reperfusion model[J]. 解放军医学杂志（英文版）, 2012,27(3):134-142.

[1].Effect of remifentanil on toll-like receptor 4, NF-κB and IL-6 in rabbit myocardial ischemia/reperfusion model[J].Journal of Medical Colleges of PLA,2012,27(03):134-142.
Effect of remifentanil on toll-like receptor 4, NF-κB and IL-6 in rabbit myocardial ischemia/reperfusion model[J]. 解放军医学杂志（英文版）, 2012,27(3):134-142. DOI：

[1].Effect of remifentanil on toll-like receptor 4, NF-κB and IL-6 in rabbit myocardial ischemia/reperfusion model[J].Journal of Medical Colleges of PLA,2012,27(03):134-142. DOI：

摘要

Abstract

Objective:To investigate whether remifentanil induced cardioprotecting effect is associated with expression of toll-like receptor 4（TLR4）

nuclear factor κB（NF-κB） and serum interleukin-6（IL-6）.Methods:Fifty rabbits were randomly divided into 5 groups（n=10） according to the treatment:sham operation group（group A）

ischemia-reperfusion group（group B）

low-dose remifentanil group（group C）

mediate-dose remifentanil group（group D）

and high-dose remifentanil group（group E）.Myocardial TLR4 mRNA levels

NF-κB protein expression and serum levels of IL-6 were observed in 120 min after reperfusion.Results:The myocardial expressions of TLR4 mRNA

NF-κB protein and IL-6 level in sera of groups B

D and E were elevated compared with group A.However

remifentanil significantly reduced the levels of TLR4 mRNA

NF-κB protein expression and serum IL-6 in groups C

D and E compared with group B.There were remarkable differences between the groups（P<0.01）.Conclusion:Intravenous remifentanil has protective effect against rabbit myocardial ischemia/reperfusion injury.This effect may be associated with TLR4

NF-κB expressions on myocytes and serum level of IL-6 in a dose-dependent manner.

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