Objective: To retrospectively analyze the clinical data of 275 cases of cervical cancer （CC） in our hospital

and investigate the clinicopathological parameters of cervical cancer based on the expression of p16INK4A proteins. Methods: The clinical information of 275 patients with cervical cancer were retrospectively analyzed between 2006 and 2011

including the patients’ age

clinical FIGO stage

differentiation

histologic grade

infiltration depth

treatment

pathological diagnosis after surgery

and results of following-up.Immunohistochemistry was also done on sections of confirmed cancer specimens without prior chemotherapy/radiotherapy. Results: Among various clinicopathological parameters

the median age was 48 years old. The grade was significantly associated with histological type

HPV infection and with lymph node invasion. FIGO stage was strongly correlated to the infiltration depth and lymph node metastasis. P16INK4A expression was significantly correlated with histologic grade. However

there were no differences between p16INK4A staining and patient’s age

histopathology and lymph node metastases. Conclusion: The incidence of cervical cancer becomes increasingly younger. Additionally

p16INK4A can function as a diagnostic marker of cervical carcinomas.