The effect of spleen on the change of Treg cells during mouse pregnancy

GAO Qing; LI Mu; ZHANG Shu; ZHOU Rui; WU Jinfang; LI Zongfang

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The effect of spleen on the change of Treg cells during mouse pregnancy

Updated：2026-03-12

- The effect of spleen on the change of Treg cells during mouse pregnancy
- The effect of spleen on the change of Treg cells during mouse pregnancy
- 解放军医学杂志（英文版） 2013年28卷第5期页码：273-280
- Affiliations：
  
  1. Department of Obstetrics and Gynecology, Second Affiliated Hospital, Medical College, Xi’an Jiaotong University
  2. Department of General Surgery, Cadres’ Ward, Second Affiliated Hospital, Medical College, Xi’an Jiaotong University
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China（NO.81070536）
- DOI：
  中图分类号： R329
- 纸质出版：2013
- Accepted：
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The effect of spleen on the change of Treg cells during mouse pregnancy[J]. 解放军医学杂志（英文版）, 2013,28(5):273-280.

[1]GAO Qing,LI Mu,ZHANG Shu,ZHOU Rui,WU Jinfang,LI Zongfang.The effect of spleen on the change of Treg cells during mouse pregnancy[J].Journal of Medical Colleges of PLA,2013,28(05):273-280.
The effect of spleen on the change of Treg cells during mouse pregnancy[J]. 解放军医学杂志（英文版）, 2013,28(5):273-280. DOI：

[1]GAO Qing,LI Mu,ZHANG Shu,ZHOU Rui,WU Jinfang,LI Zongfang.The effect of spleen on the change of Treg cells during mouse pregnancy[J].Journal of Medical Colleges of PLA,2013,28(05):273-280. DOI：

摘要

Abstract

Objective:To analyze the effect of spleen on the Treg cells during pregnancy. Methods: The mononuclear cells were separated from the peripheral

spleen and uterus or placenta blood. Flow cytometry was employed to analyze the percent of Treg cells in total T cells in different stages of pregnancy. Immunohistochemical staining was used to make sure the distribution of Treg in spleen in different stages of pregnancy. Results: The results of immunohistochemical staining showed that compared with spleen Treg cells in normal unpregnant mice

spleen Treg cells on day 7 and 14 of pregnancy significantly increased. After splenectomy

peripheral blood and placenta Treg cells on day 7 of pregnancy markedly decreased as compared with the normal pregnancy（P<0.01）. And the cells on day 14of pregnancy were markedly recovered as compared with the normal pregnancy. Conclusion: Our study indicated that the spleen and its Treg cells might play important roles in transient tolerance during pregnancy.

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