Characteristics of short double stranded RNA against hepatitis C virus: a literature-based analysis

WU Wenbin

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Characteristics of short double stranded RNA against hepatitis C virus: a literature-based analysis

Updated：2026-03-12

- Characteristics of short double stranded RNA against hepatitis C virus: a literature-based analysis
- Characteristics of short double stranded RNA against hepatitis C virus: a literature-based analysis
- 解放军医学杂志（英文版） 2013年28卷第3期页码：139-151
- Affiliations：
  
  Department of Epidemiology, Institute of Navy Medicine
- Author bio：
- Funds：
  
  Supported by Grants from the Committee of Science and Technology of Shanghai, China （No.10ZR1413100, and No.114119a1400）
- DOI：
  中图分类号： R512.63
- 纸质出版：2013
- Accepted：
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Characteristics of short double stranded RNA against hepatitis C virus: a literature-based analysis[J]. 解放军医学杂志（英文版）, 2013,28(3):139-151.

[1]WU Wenbin.Characteristics of short double stranded RNA against hepatitis C virus: a literature-based analysis[J].Journal of Medical Colleges of PLA,2013,28(03):139-151.
Characteristics of short double stranded RNA against hepatitis C virus: a literature-based analysis[J]. 解放军医学杂志（英文版）, 2013,28(3):139-151. DOI：

[1]WU Wenbin.Characteristics of short double stranded RNA against hepatitis C virus: a literature-based analysis[J].Journal of Medical Colleges of PLA,2013,28(03):139-151. DOI：

摘要

Abstract

Objective: To describe the characteristics of short interfering double stranded RNA （dsRNA） against hepatitis C virus （HCV） and to find out the determining factors in design for desirable inhibitory efficacy. Methods: The data were collected and analyzed by retrieval of 229 published short dsRNAs designed for degradation of HCV RNA. Results: Statistical analyses showed that the most frequently involved short dsRNAs were directing against 5′NTR/core and genotype 1b

accounting for 64.2% and 69.9%

respectively. Inhibitory efficacy varied with the structural characteristics of short dsRNAs

of which the most potential were those directed against HCV core region with inhibitory efficacy of 70.2%. Moreover

the mean inhibitory efficacy of short dsRNAs with GC contents from 30% to 52% was higher than that of those with GC contents out of this range. Conclusion: Based on this pooled data in a relatively large sample

the present results provided clues to design for short dsRNAs with more potent inhibitory efficacy.

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