Hepatic stellate cells（HSCs） are a kind of fat-storing cells

the lipid droplets are rich in the Cytoplasm

in which retinyl ester accounts for 42%

triglyceride occupies 28%

cholesterol（total） occupies 13%

phospholipids occupies 4% respectively. Studies have confirmed that thetransforms of HSC phenotype follows the changing of the cell lipid. After the activation of HSC

with HSC phenotype changing from fat-storing cells into myofibroblast

the lipid droplets decreased or disappeared gradually

which means HSCs are under the differentiating process of removing adipose

meawhile triglyceride

and the main content of lipid droplets

also obviously reduced. It was ever declined that during the process of HSC re-fating

the activated HSC would turn into quiescent state. Therefore this shows HSCs fat metabolism is closely related to the biological activity.