Effect of ziprasidone on QTc interval in Chinese patients with schizophrenia

YANG Xiaobo; YUAN Zuyi; CAO Hongmei; MA Xiancang

Your Location：

Home >

Browse articles >

Effect of ziprasidone on QTc interval in Chinese patients with schizophrenia

Updated：2026-03-12

- Effect of ziprasidone on QTc interval in Chinese patients with schizophrenia
- Effect of ziprasidone on QTc interval in Chinese patients with schizophrenia
- 解放军医学杂志（英文版） 2013年28卷第6期页码：368-372
- Affiliations：
  
  Department of Psychiatry, the First affiliated Hospital, Medical School of Xi’an Jiaotong University
- Author bio：
- Funds：
  
  Supported by the Natural Science Foundation of Shaanxi Province（2011JM4008）
- DOI：
  中图分类号： R742.3
- 纸质出版：2013
- Accepted：
Scan QR Code
Effect of ziprasidone on QTc interval in Chinese patients with schizophrenia[J]. 解放军医学杂志（英文版）, 2013,28(6):368-372.

[1]YANG Xiaobo,YUAN Zuyi,CAO Hongmei,MA Xiancang.Effect of ziprasidone on QTc interval in Chinese patients with schizophrenia[J].Journal of Medical Colleges of PLA,2013,28(06):368-372.
Effect of ziprasidone on QTc interval in Chinese patients with schizophrenia[J]. 解放军医学杂志（英文版）, 2013,28(6):368-372. DOI：

[1]YANG Xiaobo,YUAN Zuyi,CAO Hongmei,MA Xiancang.Effect of ziprasidone on QTc interval in Chinese patients with schizophrenia[J].Journal of Medical Colleges of PLA,2013,28(06):368-372. DOI：

摘要

Abstract

Objective: To investigate the effect of ziprasidone on QTc in Chinese patients with schizophrenia. Methods: The study involved 27 patients with schizophrenia. Ziprasidone was initiated with 40 mg/day. From day 3 to day 7

the dose was increased gradually to 120-160 mg/d according to the effectiveness and tolerability. QTc values were measured at the beginning and month 6. Results: At the beginning of the 6 months treatment

the mean QTc interval of patients was（387.5±19.0） ms. At the end of the study

it was（402.9±23.6） ms. The difference has statistically significance（P<0.05）. The mean QTc interval changed significantly throughout 6-months period but no one exceed the QTc dangerous limits. Significant correlation was found between QTc interval and the dose. Conclusion: In summary

our results suggest that ziprasidone has good tolerance in patient with schizophrenia despite its dose-related QTc prolongation. Ziprasidone have no pro-arrhythmic profile.

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据