There were very few reports of adverse effects in patients treated by liver resection in combination with sorafenib. We present 5 cases of hepatocellular carcinoma treated with liver resection plus sorafenib

trying to observing the adverse effects and seeking the nursing options to the adverse effects. The 5 patients were all males

and the mean age was （38.6±13.4） years. Tumor sizes were （6.7±2.2） cm

and liver function was Child-Pugh class A. Diagnosis of Hepatocellular carcinoma （HCC） was confirmed by postoperative pathology. During the follow-ups

all the 5 patients had different degrees of adverse effects

of which 5 patients had diarrhea

3 had hand-foot skin reaction

1 had hypertension and 1 had alopecie. Diarrhea seems common in these patients

and it appeared early after treatment. For those patients with adverse effects

management measures were given immediately

including nursing interventions and some medicines. Psychological and symptomatic nursing guidance can help patients overcome the adverse effects. No patients suffered dose reduction or treatment discontinuation.