Primary prevention of posttraumatic stress disorder: drugs and implications

Joachim C Burbiel

Your Location：

Home >

Browse articles >

Primary prevention of posttraumatic stress disorder: drugs and implications

REVIEW | Updated：2022-12-27

- Primary prevention of posttraumatic stress disorder: drugs and implications
- Primary prevention of posttraumatic stress disorder: drugs and implications
- MMR 2015年2卷第3期页码：156-162
- Affiliations：
  
  Fraunhofer Institute for Technological Trend Analysis INT, Appelsgarten 2, 53879 Euskirchen, Germany
- Author bio：
  
  *: joachim.burbiel@int.fraunhofer.de
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2015-09
- Accepted：
Scan QR Code
Primary prevention of posttraumatic stress disorder: drugs and implications[J]. MMR, 2015,2(3):156-162.

Joachim C Burbiel. Primary prevention of posttraumatic stress disorder: drugs and implications[J]. Military Medical Research, 2015, 2(3): 156-162.
Primary prevention of posttraumatic stress disorder: drugs and implications[J]. MMR, 2015,2(3):156-162. DOI：

Joachim C Burbiel. Primary prevention of posttraumatic stress disorder: drugs and implications[J]. Military Medical Research, 2015, 2(3): 156-162. DOI：

摘要

Abstract

Because posttraumatic stress disorder (PTSD) is a highly debilitating condition

prevention is an important research topic. This article reviews possible prevention approaches that involve the administration of drugs before the traumatic event takes place. The considered approaches include drugs that address the sympathetic nervous system

drugs interfere with the hypothalamic-pituitary-adrenal (HPA) axis

narcotics and other psychoactive drugs

as well as modulators of protein synthesis. Furthermore

some thoughts on potential ethical implications of the use of drugs for the primary prevention of PTDS are presented. While there are many barriers to overcome in this field of study

this paper concludes with a call for additional research

as there are currently no approaches that are well-suited for regular daily use.

关键词

Keywords

references

McCleery JM , Harvey AG . Integration of psychological and biological approaches to trauma memory: implications for pharmacological prevention of PTSD . J Trauma Stress . 2004 ; 17 : 485 - 96 . doi: 10.1007/s10960-004-5797-5 http://doi.org/10.1007/s10960-004-5797-5 .

Davidson , Johnathan R. T . Surviving disaster: what comes after the trauma? The British Journal of Psychiatry . 2002 ; 181 : 366 - 8 . doi: 10.1192/bjp.181.5.366 http://doi.org/10.1192/bjp.181.5.366 .

Searcy CP , Bobadilla L , Gordon WA , Jacques S , Elliott L . Pharmacological Prevention of Combat-Related PTSD: A Literature Review . Military Medicine . 2012 ; 177 : 649 - 54 .

Husky MM , Lépine J , Gasquet I , Kovess-Masfety V . Exposure to Traumatic Events and Posttraumatic Stress Disorder in France: Results From the WMH Survey . J Trauma Stress . 2015 . doi: 10.1002/jts.22020 http://doi.org/10.1002/jts.22020 .

Department of Veterans Affairs , Veterans Health Administration , Office of Public Health , Post-Deployment Health Group . Report on VA Facility Specific Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans Diagnosed with Potential or Provisional PTSD . http://www.publichealth.va.gov/docs/epidemiology/ptsd-report-fy2014-qtr1.pdf http://www.publichealth.va.gov/docs/epidemiology/ptsd-report-fy2014-qtr1.pdf . Accessed 27 Aug 2015 .

Reno J . Nearly 30% of Vets Treated by V.A. Have PTSD: A new study by the Veterans Administration reveals nearly 30% of its patients who served in Iraq and Afghanistan have PTSD . 2012 . http://www.thedailybeast.com/articles/2012/10/21/nearly-30-of-vets-treated-by-v-a-have-ptsd.html http://www.thedailybeast.com/articles/2012/10/21/nearly-30-of-vets-treated-by-v-a-have-ptsd.html . Accessed 24 Mar 2015 .

Richardson LK , Frueh BC , Acierno R . Prevalence estimates of combat-related post-traumatic stress disorder: critical review . Aust N Z J Psychiatry . 2010 ; 44 : 4 - 19 . doi: 10.3109/00048670903393597 http://doi.org/10.3109/00048670903393597 .

MacGregor AJ , Dougherty AL , Mayo JA , Han PP , Galarneau MR . Post-traumatic Stress Disorder Among Navy Health Care Personnel Following Combat Deployment . Military Medicine . 2015 ; 180 : 882 - 7 . doi: 10.7205/MILMED-D-14-00323 http://doi.org/10.7205/MILMED-D-14-00323 .

Johns B , Hall K , Hoxeng D , Steve Bird - Spindustry Systems , com ws . CNS Spectrums: Can Posttraumatic Stress Disorder be Prevented? 2009 . http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=1967 http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=1967 . Accessed 24 Mar 2015 .

Steckler T , Risbrough V . Pharmacological treatment of PTSD - established and new approaches . Neuropharmacology . 2012 ; 62 : 617 - 27 . doi: 10.1016/j.neuropharm.2011.06.012 http://doi.org/10.1016/j.neuropharm.2011.06.012 .

Bruchhausen Fv , Albinus M . Hagers Handbuch der pharmazeutischen Praxis. 5. vollst. neubearb . Aufl. Berlin [etc.] : Springer ; 1992-1994 .

Mutschler E . Arzneimittelwirkungen: Lehrbuch der Pharmakologie und Toxikologie ; mit einführenden Kapiteln in die Anatomie, Physiologie und Pathophysiologie. 6., völlig neubearb. und erw . Aufl. Stuttgart : Wiss. Verl.-Ges. ; 1991 .

Introini-Collison I , Saghafi D , Novack GD , McGaugh JL . Memory-enhancing effects of post-training dipivefrin and epinephrine: Involvement of peripheral and central adrenergic receptors . Brain Research . 1992 ; 572 : 81 - 6 . doi: 10.1016/0006-8993(92)90454-H http://doi.org/10.1016/0006-8993(92)90454-H .

van Stegeren , Anda H. , Everaerd W , Cahill L , McGaugh JL , Gooren , Louis J. G . Memory for emotional events: differential effects of centrally versus peripherally acting β-blocking agents . Psychopharmacology . 1998 ; 138 : 305 - 10 . doi: 10.1007/s002130050675 http://doi.org/10.1007/s002130050675 .

Hoge EA , Worthington JJ , Nagurney JT , Chang Y , Kay EB , Feterowski CM , et al . Effect of acute posttrauma propranolol on PTSD outcome and physiological responses during script-driven imagery . CNS Neurosci Ther . 2012 ; 18 : 21 - 7 . doi: 10.1111/j.1755-5949.2010.00227.x http://doi.org/10.1111/j.1755-5949.2010.00227.x .

Lonergan MH , Olivera-Figueroa LA , Pitman RK , Brunet A . Propranolol’s effects on the consolidation and reconsolidation of long-term emotional memory in healthy participants: a meta-analysis . J Psychiatry Neurosci . 2013 ; 38 : 222 - 31 . doi: 10.1503/jpn.120111 http://doi.org/10.1503/jpn.120111 .

Cahill L , Prins B , Weber M , McGaugh JL . Beta-adrenergic activation and memory for emotional events . Nature . 1994 ; 371 : 702 - 4 . doi: 10.1038/371702a0 http://doi.org/10.1038/371702a0 .

Schwabe L , Nader K , Pruessner JC . β-Adrenergic blockade during reactivation reduces the subjective feeling of remembering associated with emotional episodic memories . Biol Psychol . 2013 ; 92 : 227 - 32 . doi: 10.1016/j.biopsycho.2012.10.003 http://doi.org/10.1016/j.biopsycho.2012.10.003 .

Raskind MA . Prazosin for the Treatment of PTSD . Curr Treat Options Psych . 2015 ; 2 : 192 - 203 . doi: 10.1007/s40501-015-0040-y http://doi.org/10.1007/s40501-015-0040-y .

Green B . Prazosin in the treatment of PTSD . J Psychiatr Pract . 2014 ; 20 : 253 - 9 . doi: 10.1097/01.pra.0000452561.98286.1e http://doi.org/10.1097/01.pra.0000452561.98286.1e .

Raskind MA , Peskind ER , Hoff DJ , Hart KL , Holmes HA , Warren D , et al . A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder . Biological Psychiatry . 2007 ; 61 : 928 - 34 . doi: 10.1016/j.biopsych.2006.06.032 http://doi.org/10.1016/j.biopsych.2006.06.032 .

Gibbs ME , Summers RJ . Stimulation of alpha1-adrenoceptors inhibits memory consolidation in the chick . Eur J Neurosci . 2001 ; 14 : 1369 - 76 . doi: 10.1046/j.0953-816x.2001.01742.x http://doi.org/10.1046/j.0953-816x.2001.01742.x .

Manion ST . Amygdala, Anxiety and Alpha(1) Adrenoceptors: Investigations Utilizing a Rodent Model of Traumatic Stress . 2006 . http://www.dtic.mil/docs/citations/ADA459042 http://www.dtic.mil/docs/citations/ADA459042 . Accessed 23 Jul 2015 .

Schelling G , Briegel J , Roozendaal B , Stoll C , Rothenhäusler H , Kapfhammer H . The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors . Biological Psychiatry . 2001 ; 50 : 978 - 85 . doi: 10.1016/S0006-3223(01)01270-7 http://doi.org/10.1016/S0006-3223(01)01270-7 .

Cohen H , Matar MA , Buskila D , Kaplan Z , Zohar J . Early post-stressor intervention with high-dose corticosterone attenuates posttraumatic stress response in an animal model of posttraumatic stress disorder . Biological Psychiatry . 2008 ; 64 : 708 - 17 . doi: 10.1016/j.biopsych.2008.05.025 http://doi.org/10.1016/j.biopsych.2008.05.025 .

Holbrook TL , Galarneau MR , Dye JL , Quinn K , Dougherty AL . Morphine use after combat injury in Iraq and post-traumatic stress disorder . N Engl J Med . 2010 ; 362 : 110 - 7 . doi: 10.1056/NEJMoa0903326 http://doi.org/10.1056/NEJMoa0903326 .

McGhee LL , Maani CV , Garza TH , Gaylord KM , Black IH . The correlation between ketamine and posttraumatic stress disorder in burned service members . J Trauma . 2008 ; 64 : S195-8; Discussion S197-8 . doi: 10.1097/TA.0b013e318160ba1d http://doi.org/10.1097/TA.0b013e318160ba1d .

Zhang W , Davidson , Johnathan R. T . Post-traumatic stress disorder: an evaluation of existing pharmacotherapies and new strategies . Expert Opin Pharmacother . 2007 ; 8 : 1861 - 70 .

Guina J , Rossetter SR , DeRHODES BJ , Nahhas RW , Welton RS . Benzodiazepines for PTSD: A Systematic Review and Meta-Analysis . J Psychiatr Pract . 2015 ; 21 : 281 - 303 . doi: 10.1097/PRA.0000000000000091 http://doi.org/10.1097/PRA.0000000000000091 .

Kozlovsky N , Kaplan Z , Zohar J , Matar MA , Shimon H , Cohen H . Protein synthesis inhibition before or after stress exposure results in divergent endocrine and BDNF responses disassociated from behavioral responses . Depress Anxiety . 2008 ; 25 : E24 - 34 . doi: 10.1002/da.20366 http://doi.org/10.1002/da.20366 .

Gold PE . Protein synthesis inhibition and memory: formation vs amnesia . Neurobiol Learn Mem . 2008 ; 89 : 201 - 11 . doi: 10.1016/j.nlm.2007.10.006 http://doi.org/10.1016/j.nlm.2007.10.006 .

Andero R , Dias BG , Ressler KJ . A role for Tac2, NkB, and Nk3 receptor in normal and dysregulated fear memory consolidation . Neuron . 2014 ; 83 : 444 - 54 . doi: 10.1016/j.neuron.2014.05.028 http://doi.org/10.1016/j.neuron.2014.05.028 .

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Hippocampal PACAP signaling activation triggers a rapid antidepressant response

Chinese expert consensus on prevention, diagnosis, and management of venous thromboembolism in adult burn patients (2024)

Dexamethasone for prevention of AMS, HACE, and HAPE and for limiting impairment of performance after rapid ascent to high altitude: a narrative review

Risk factors for musculoskeletal injuries in the military: a qualitative systematic review of the literature from the past two decades and a new prioritizing injury model

Quetiapine augmentation of prolonged exposure therapy in veterans with PTSD and a history of mild traumatic brain injury: design and methodology of a pilot study