Ebola virus disease: From epidemiology to prophylaxis

Wen-Bin Liu; Zi-Xiong Li; Yan Du; Guang-Wen Cao

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Ebola virus disease: From epidemiology to prophylaxis

REVIEW | Updated：2022-12-27

- Ebola virus disease: From epidemiology to prophylaxis
- Ebola virus disease: From epidemiology to prophylaxis
- MMR 2014年1卷第4期页码：208-216
- Affiliations：
  
  Department of Epidemiology, Second Military Medical University, Shanghai 200433, China
- Author bio：
  
  *: gcao@smmu.edu.cn
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2014-12
- Accepted：
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Ebola virus disease: From epidemiology to prophylaxis[J]. MMR, 2014,1(4):208-216.

Liu et al.: Ebola virus disease: From epidemiology to prophylaxis. Mil Med Res 2014
Ebola virus disease: From epidemiology to prophylaxis[J]. MMR, 2014,1(4):208-216. DOI：

Liu et al.: Ebola virus disease: From epidemiology to prophylaxis. Mil Med Res 2014 DOI：

摘要

Abstract

The outbreak of Ebola virus disease (EVD) continues to spread through West Africa. Since the first reported EVD in March 2014

the number of cases has increased rapidly

with the fatality rate of >50%. The most prevalent Ebola virus belongs to the species of Zaire ebolavirus

with a mortality rate as high as 90%. Although there were introduced cases in other continents

Africa is the endemic area where fruit bats and apes are suspected to be Ebola virus carriers. The virus might be transmitted from the host animals to humans if humans consume relative raw and contaminated meats; however

human-to-human transmission via close contact is the major route of current outbreaks. EVD happens at any seasons and affected people of any race in any age groups. Direct contact with body fluids of EVD patients and living in the contaminated environment greatly increase the risk of being infected. Transmission via aerosol is less possible but the transmission via droplet is possible in humans. Thus

health care providers are facing danger of getting Ebola virus infection. So far

there are limited vaccines

drugs and/or therapies to prevent Ebola virus infection or treat EVD. Medical workers should follow the current standard prophylactic procedures. Military forces can orchestrate efficient care to mass EVD casualties. Although it is necessary to speed up the pace of developing effective vaccine and therapeutics for the prevention and treatment of EVD

public health prophylaxis is the most important issue at present to control the spread of this disease cost-effectively.

关键词

Keywords

references

Lemaitre C , Harper F , Pierron G , Heidmann T , Dewannieux M : The HERV-K human endogenous retrovirus envelope protein antagonizes tetherin antiviral activity . J Virol 2014 , 88 : 13626 - 13637 .

Pandey A , Atkins KE , Medlock J , Wenzel N , Townsend JP , Childs JE , Nyenswah TG , Ndeffo-Mbah ML , Galvani AP : Strategies for containing Ebola in West Africa . Science 2014 , 346 : 991 - 995 .

WHO Ebola Response Team : Ebola virus disease in West Africa--the first 9 months of the epidemic and forward projections . N Engl J Med 2014 , 371 : 1481 - 1495 .

Johnson KM , Lange JV , Webb PA , Murphy FA : Isolation and partial characterisation of a new virus causing acute haemorrhagic fever in Zaire . Lancet 1977 , 1 : 569 - 571 .

Kuhn JH , Dodd LE , Wahl-Jensen V , Radoshitzky SR , Bavari S , Jahrling PB : Evaluation of perceived threat differences posed by filovirus variants . Biosecur Bioterror 2011 , 9 : 361 - 371 .

Bishop BM : Potential and emerging treatment options for Ebola virus disease . Ann Pharmacother 2015 , 49 : 196 - 206 .

Geisbert TW , Geisbert JB , Leung A , Daddario-DiCaprio KM , Hensley LE , Grolla A , Feldmann H : Single-injection vaccine protects nonhuman primates against infection with marburg virus and three species of ebola virus . J Virol 2009 , 83 : 7296 - 7304 .

Stanley DA , Honko AN , Asiedu C , Trefry JC , Lau-Kilby AW , Johnson JC , Hensley L , Ammendola V , Abbate A , Grazioli F , Foulds KE , Cheng C , Wang L , Donaldson MM , Colloca S , Folgori A , Roederer M , Nabel GJ , Mascola J , Nicosia A , et al : Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge . Nat Med 2014 , 20 : 1126 - 1129 .

Qiu X , Wong G , Audet J , Bello A , Fernando L , Alimonti JB , Fausther-Bovendo H , Wei H , Aviles J , Hiatt E , Johnson A , Morton J , Swope K , Bohorov O , Bohorova N , Goodman C , Kim D , Pauly MH , Velasco J , Pettitt J , et al : Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp . Nature 2014 , 514 : 47 - 53 .

Brès P : The epidemic of Ebola haemorrhagic fever in Sudan and Zaire, 1976: introductory note . Bull World Health Organ 1978 , 56 : 245 .

Baron RC , McCormick JB , Zubeir OA : Ebola virus disease in southern Sudan: hospital dissemination and intrafamilial spread . Bull World Health Organ 1983 , 61 : 997 - 1003 .

Georges AJ , Leroy EM , Renaut AA , Benissan CT , Nabias RJ , Ngoc MT , Obiang PI , Lepage JP , Bertherat EJ , Bénoni DD , Wickings EJ , Amblard JP , Lansoud-Soukate JM , Milleliri JM , Baize S , Georges-Courbot MC : Ebola hemorrhagic fever outbreaks in Gabon, 1994-1997: epidemiologic and health control issues . J Infect Dis 1999 , 179 Suppl1 : S65 - S75 .

Le Guenno B , Formenty P , Wyers M , Gounon P , Walker F , Boesch C : Isolation and partial characterisation of a new strain of Ebola virus . Lancet 1995 , 345 : 1271 - 1274 .

Muyembe-Tamfum JJ , Mulangu S , Masumu J , Kayembe JM , Kemp A , Paweska JT : Ebola virus outbreaks in Africa: past and present . Onderstepoort J Vet Res 2012 , 79 : 451 .

Towner JS , Sealy TK , Khristova ML , Albariño CG , Conlan S , Reeder SA , Quan PL , Lipkin WI , Downing R , Tappero JW , Okware S , Lutwama J , Bakamutumaho B , Kayiwa J , Comer JA , Rollin PE , Ksiazek TG , Nichol ST : Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda . PLoS Pathogens 2008 , 4 : e1000212 .

[No authors listed] . Outbreak news. Ebola, democratic republic of the Congo . Wkly Epidemiol Rec 2012 , 87 : 421 .

Okware SI , Omaswa FG , Zaramba S , Opio A , Lutwama JJ , Kamugisha J , Rwaguma EB , Kagwa P , Lamunu M : An outbreak of Ebola in Uganda . Trop Med Int Health 2002 , 7 : 1068 - 1075 .

[No authors listed] . Outbreak(s) of Ebola haemorrhagic fever, Congo and Gabon, October 2001-July 2002 . Wkly Epidemiol Rec 2003 , 78 : 223 - 228 .

Formenty P , Libama F , Epelboin A , Allarangar Y , Leroy E , Moudzeo H , Tarangonia P , Molamou A , Lenzi M , Ait-Ikhlef K , Hewlett B , Roth C , Grein T : Outbreak of Ebola hemorrhagic fever in the Republic of the Congo, 2003: a new strategy? Med Trop (Mars) 2003 , 63 : 291 - 295 .

Centers for disease control and prevention : Ebola virus disease distribution-map . http://www.cdc.gov/vhf/ebola/outbreaks/history/distribution-map http://www.cdc.gov/vhf/ebola/outbreaks/history/distribution-map .

Mbonye A , Wamala J , Winyi K , Tugumizemo V , Aceng J , Makumbi I : Repeated outbreaks of viral hemorrhagic fevers in Uganda . Afr Health Sci 2012 , 12 : 579 - 583 .

Feldmann H , Geisbert TW : Ebola haemorrhagic fever . Lancet 2011 , 377 : 849 - 862 .

Maganga GD , Kapetshi J , Berthet N , Kebela Ilunga B , Kabange F , Mbala Kingebeni P , Mondonge V , Muyembe JJ , Bertherat E , Briand S , Cabore J , Epelboin A , Formenty P , Kobinger G , González-Angulo L , Labouba I , Manuguerra JC , Okwo-Bele JM , Dye C , et al : Ebola virus disease in the Democratic Republic of Congo . New Engl J Med 2014 , 371 : 2083 - 2091 .

Schieffelin JS , Shaffer JG , Goba A , Gbakie M , Gire SK , Colubri A , Sealfon RS , Kanneh L , Moigboi A , Momoh M , Fullah M , Moses LM , Brown BL , Andersen KG , Winnicki S , Schaffner SF , Park DJ , Yozwiak NL , Jiang PP , Kargbo D , et al : Clinical illness and outcomes in patients with Ebola in Sierra Leone . N Engl J Med 2014 , 371 : 2092 - 2100 .

Matanock A , Arwady MA , Ayscue P , Forrester JD , Gaddis B , Hunter JC , Monroe B , Pillai SK , Reed C , Schafer IJ , Massaquoi M , Dahn B , De Cock KM; Centers for Disease Control and Prevention (CDC) : Ebola virus disease cases among health care workers not working in ebola treatment units - liberia, june-august, 2014 . MMWR Morb Mortal Wkly Rep 2014 , 63 : 1077 - 1081 .

Rasmussen AL , Okumura A , Ferris MT , Green R , Feldmann F , Kelly SM , Scott DP , Safronetz D , Haddock E , LaCasse R , Thomas MJ , Sova P , Carter VS , Weiss JM , Miller DR , Shaw GD , Korth MJ , Heise MT , Baric RS , de Villena FP , et al : Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance . Science 2014 , 346 : 987 - 991 .

Kuhn JH , Becker S , Ebihara H , Geisbert TW , Johnson KM , Kawaoka Y , Lipkin WI , Negredo AI , Netesov SV , Nichol ST , Palacios G , Peters CJ , Tenorio A , Volchkov VE , Jahrling PB : Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations . Arch Virol 2010 , 155 : 2083 - 2103 .

Groseth A , Feldmann H , Strong JE : The ecology of Ebola virus . Trends Microbiol 2007 , 15 : 408 - 416 .

Gire SK , Goba A , Andersen KG , Sealfon RS , Park DJ , Kanneh L , Jalloh S , Momoh M , Fullah M , Dudas G , Wohl S , Moses LM , Yozwiak NL , Winnicki S , Matranga CB , Malboeuf CM , Qu J , Gladden AD , Schaffner SF , Yang X , et al : Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak . Science 2014 , 345 : 1369 - 1372 .

Carroll SA , Towner JS , Sealy TK , McMullan LK , Khristova ML , Burt FJ , Swanepoel R , Rollin PE , Nichol ST : Molecular evolution of viruses of the family Filoviridae based on 97 whole-genome sequences . J Virol 2013 , 87 : 2608 - 2616 .

Basler CF , Wang X , Muhlberger E , Volchkov V , Paragas J , Klenk HD , Garcia-Sastre A , Palese P : The Ebola virus VP35 protein functions as a type I IFN antagonist . Proc Natl Acad Sci USA 2000 , 97 : 12289 - 12294 .

Reid SP , Leung LW , Hartman AL , Martinez O , Shaw ML , Carbonnelle C , Volchkov VE , Nichol ST , Basler CF : Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation . J Virol 2006 , 80 : 5156 - 5167 .

Kindzelskii AL , Yang Z , Nabel GJ , Todd RF, 3rd , Petty HR : Ebola virus secretory glycoprotein (sGP) diminishes Fc gamma RIIIB-to-CR3 proximity on neutrophils . J Immunol 2000 , 164 : 953 - 958 .

Ito H , Watanabe S , Takada A , Kawaoka Y : Ebola virus glycoprotein: proteolytic processing, acylation, cell tropism, and detection of neutralizing antibodies . J Virol 2001 , 75 : 1576 - 1580 .

Mitchell SW , McCormick JB : Physicochemical inactivation of Lassa, Ebola, and Marburg viruses and effect on clinical laboratory analyses . J Clin Microbiol 1984 , 20 : 486 - 489 .

Rodriguez LL , De Roo A , Guimard Y , Trappier SG , Sanchez A , Bressler D , Williams AJ , Rowe AK , Bertolli J , Khan AS , Ksiazek TG , Peters CJ , Nichol ST : Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo, 1995 . J Infect Dis 1999 , 179 Suppl 1 : S170 - 176 .

Zaki SR , Shieh WJ , Greer PW , Goldsmith CS , Ferebee T , Katshitshi J , Tshioko FK , Bwaka MA , Swanepoel R , Calain P , Khan AS , Lloyd E , Rollin PE , Ksiazek TG , Peters CJ : A novel immunohistochemical assay for the detection of Ebola virus in skin: implications for diagnosis, spread, and surveillance of Ebola hemorrhagic fever. Commission de Lutte contre les Epidemies a Kikwit . J Infect Dis 1999 , 179 Suppl 1 : S36 - S47 .

Drazen JM , Kanapathipillai R , Campion EW , Rubin EJ , Hammer SM , Morrissey S , Baden LR : Ebola and quarantine . New Engl J Med 2014 , 371 : 2029 - 2030 .

Rowe AK , Bertolli J , Khan AS , Mukunu R , Muyembe-Tamfum JJ , Bressler D , Williams AJ , Peters CJ , Rodriguez L , Feldmann H , Nichol ST , Rollin PE , Ksiazek TG : Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo. Commission de Lutte contre les Epidemies a Kikwit . J Infect Dis 1999 , 179 Suppl 1 : S28 - S35 .

Chan M : Ebola virus disease in West Africa--no early end to the outbreak . New Engl J Med 2014 , 371 : 1183 - 1185 .

Samaranayake LP , Peiris JS , Scully C : Ebola virus infection: an overview . Br Dent J 1996 , 180 : 264 - 266 .

Tomori O , Bertolli J , Rollin PE , Fleerackers Y , Guimard Y , De Roo A , Feldmann H , Burt F , Swanepoel R , Killian S , Khan AS , Tshioko K , Bwaka M , Ndambe R , Peters CJ , Ksiazek TG : Serologic survey among hospital and health center workers during the Ebola hemorrhagic fever outbreak in Kikwit, Democratic Republic of the Congo, 1995 . J Infect Dis 1999 , 179 Suppl 1 : S98 - S101 .

Swanepoel R , Leman PA , Burt FJ , Zachariades NA , Braack LE , Ksiazek TG , Rollin PE , Zaki SR , Peters CJ : Experimental inoculation of plants and animals with Ebola virus . Emerg Infect Dis 1996 , 2 : 321 - 325 .

Leroy EM , Kumulungui B , Pourrut X , Rouquet P , Hassanin A , Yaba P , Delicat A , Paweska JT , Gonzalez JP , Swanepoel R : Fruit bats as reservoirs of Ebola virus . Nature 2005 , 438 : 575 - 576 .

[No authors listed] . Ebola haemorrhagic fever in Sudan, 1976. Report of a WHO /International Study Team . Bull World Health Organ 1978 , 56 : 247 - 270 .

[No authors listed] . Ebola haemorrhagic fever in Zaire, 1976 . Bull World Health Organ 1978 , 56 : 271 - 293 .

Goeijenbier M , van Kampen JJ , Reusken CB , Koopmans MP , van Gorp EC : Ebola virus disease: a review on epidemiology, symptoms, treatment and pathogenesis . Neth J Med 2014 , 72 : 442 - 448 .

Pourrut X , Delicat A , Rollin PE , Ksiazek TG , Gonzalez JP , Leroy EM : Spatial and temporal patterns of Zaire ebolavirus antibody prevalence in the possible reservoir bat species . J Infect Dis 2007 , 196 Suppl 2 : S176 - S183 .

Leroy EM , Epelboin A , Mondonge V , Pourrut X , Gonzalez JP , Muyembe-Tamfum JJ , Formenty P : Human Ebola outbreak resulting from direct exposure to fruit bats in Luebo, Democratic Republic of Congo, 2007 . Vector Borne Zoonotic Dis 2009 , 9 : 723 - 728 .

Jaax NK , Davis KJ , Geisbert TJ , Vogel P , Jaax GP , Topper M , Jahrling PB : Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure . Arch Pathol Lab Med 1996 , 120 : 140 - 155 .

Georges-Courbot MC , Sanchez A , Lu CY , Baize S , Leroy E , Lansout-Soukate J , Tévi-Bénissan C , Georges AJ , Trappier SG , Zaki SR , Swanepoel R , Leman PA , Rollin PE , Peters CJ , Nichol ST , Ksiazek TG : Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in Gabon . Emerg Infect Dis 1997 , 3 : 59 - 62 .

Barrette RW , Metwally SA , Rowland JM , Xu L , Zaki SR , Nichol ST , Rollin PE , Towner JS , Shieh WJ , Batten B , Sealy TK , Carrillo C , Moran KE , Bracht AJ , Mayr GA , Sirios-Cruz M , Catbagan DP , Lautner EA , Ksiazek TG , White WR , et al : Discovery of swine as a host for the Reston ebolavirus . Science 2009 , 325 : 204 - 206 .

Chowell G , Nishiura H : Transmission dynamics and control of Ebola virus disease (EVD): a review . BMC Med 2014 , 12 : 196 .

Irving WL : Ebola virus transmission . Int J Exp Pathol 1995 , 76 : 225 - 226 .

Weingartl HM , Embury-Hyatt C , Nfon C , Leung A , Smith G , Kobinger G : Transmission of Ebola virus from pigs to non-human primates . Sci Rep 2012 , 2 : 811 .

World Health Organization : Ebola response roadmap situation report. 2014 . http://www.who.int/csr/disease/ebola/situation-reports/en http://www.who.int/csr/disease/ebola/situation-reports/en .

Omonzejele PF : Ethical challenges posed by the Ebola virus epidemic in West Africa . J Bioeth Inq 2014 , 11 : 417 - 420 .

Strom BL , Buyse M , Hughes J , Knoppers BM : Data sharing, year 1--access to data from industry-sponsored clinical trials . New Engl J Med 2014 , 371 : 2052 - 2054 .

Katz LM , Tobian AA : Ebola virus disease, transmission risk to laboratory personnel, and pretransfusion testing . Transfusion 2014 , 54 : 3247 - 3251 .

Hussain M : MSF calls for military medics to help tackle west Africa Ebola . Thomas Reuters Foundation , 2014 . http://www.trust.org/item/20140902150401-egnh8/ http://www.trust.org/item/20140902150401-egnh8/ .

UN Mission for Ebola Emergency Response . http://www.un.org/ebolaresponse/mission.shtml http://www.un.org/ebolaresponse/mission.shtml .

Sophie Arie : Only the military can get the Ebola epidemic under control: MSF head . BMJ 2014 , 349 : 6151 - 6153 .

Larson C : China ramps up efforts to combat Ebola . Science , 2014 , [ http://news.sciencemag.org/asiapacific/2014/11/chinaramps-efforts-combat-ebola http://news.sciencemag.org/asiapacific/2014/11/chinaramps-efforts-combat-ebola ].

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