An ongoing search for potential targets and therapies for lethal sepsis

Guo-Qiang Bao; Li He; David Lee; John D’Angelo; Hai-Chao Wang

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An ongoing search for potential targets and therapies for lethal sepsis

REVIEW | Updated：2022-12-27

- An ongoing search for potential targets and therapies for lethal sepsis
- An ongoing search for potential targets and therapies for lethal sepsis
- MMR 2015年2卷第3期页码：145-155
- Affiliations：
  
  1.Department of Emergency Medicine, North Shore University Hospital, Manhasset, NY 11030, USA
  2.The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
  3.Department of General Surgery, Tangdu Hospital, The 4th Military Medical University, Xi’an, Shaanxi 710032, China
  4.Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
- Author bio：
  
  *: hwang@nshs.edu
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2015-09
- Accepted：
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An ongoing search for potential targets and therapies for lethal sepsis[J]. MMR, 2015,2(3):145-155.

Guo-Qiang Bao, Li He, David Lee, et al. An ongoing search for potential targets and therapies for lethal sepsis[J]. Military Medical Research, 2015, 2(3): 145-155.
An ongoing search for potential targets and therapies for lethal sepsis[J]. MMR, 2015,2(3):145-155. DOI：

Guo-Qiang Bao, Li He, David Lee, et al. An ongoing search for potential targets and therapies for lethal sepsis[J]. Military Medical Research, 2015, 2(3): 145-155. DOI：

摘要

Abstract

Sepsis

which refers to a systemic inflammatory response syndrome resulting from a microbial infection

represents the leading cause of death in intensive care units. The pathogenesis of sepsis remains poorly understood although it is attributable to dysregulated immune responses orchestrated by innate immune cells that sequentially release early (e.g.

tumor necrosis factor(TNF)

interleukin-1(IL-1)

and interferon-γ(IFN-γ) and late (e.g.

high mobility group box 1(HMGB1)) pro-inflammatory mediators. As a ubiquitous nuclear protein

HMGB1 can be passively released from pathologically damaged cells

thereby converging infection and injury on commonly dysregulated inflammatory responses. We review evidence that supports extracellular HMGB1 as a late mediator of inflammatory diseases and discuss the potential of several Chinese herbal components as HMGB1-targeting therapies. We propose that it is important to develop strategies for specifically attenuating injury-elicited inflammatory responses without compromising the infection-mediated innate immunity for the clinical management of sepsis and other inflammatory diseases.

关键词

Keywords

references

Wang H , Zhu S , Zhou R , Li W , Sama AE . Therapeutic potential of HMGB1-targeting agents in sepsis . Expert Rev Mol Med . 2008 ; 10 : e32 .

Dellinger RP , Levy MM , Carlet JM , Bion J , Parker MM , Jaeschke R , et al . Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008 . Crit Care Med . 2008 ; 36 : 296 - 327 .

Angus DC , Linde-Zwirble WT , Lidicker J , Clermont G , Carcillo J , Pinsky MR . Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care . Crit Care Med . 2001 ; 29 : 1303 - 10 .

Ha T , Lu C , Liu L , Hua F , Hu Y , Kelley J , et al . TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinasedependent mechanism . Am J Physiol Heart Circ Physiol . 2010 ; 298 : H984 - 91 .

Gao M , Ha T , Zhang X , Liu L , Wang X , Kelley J , et al . Toll-like receptor 3 plays a central role in cardiac dysfunction during polymicrobial sepsis . Crit Care Med . 2012 ; 40 : 2390 - 9 .

Brightbill HD , Libraty DH , Krutzik SR , Yang RB , Belisle JT , Bleharski JR , et al . Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors . Science . 1999 ; 285 : 732 - 6 .

Poltorak A , He X , Smirnova I , Liu MY , Huffel CV , Du X , et al . Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene . Science . 1998 ; 282 : 2085 - 8 .

Hemmi H , Takeuchi O , Kawai T , Kaisho T , Sato S , Sanjo H , et al . A Toll-like receptor recognizes bacterial DNA . Nature . 2000 ; 408 : 740 - 5 .

Akira S , Takeda K . Toll-like receptor signalling . Nat Rev Immunol . 2004 ; 4 : 499 - 511 .

Baggiolini M , Loetscher P . Chemokines in inflammation and immunity . Immunol Today . 2000 ; 21 : 418 - 20 .

Chan ED , Riches DW . IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38 mapk in a mouse macrophage cell line . Am J Physiol Cell Physiol . 2001 ; 280 : C441 - 50 .

Liu QY , Yao YM . Inflammatory response and immune regulation of high mobility group box-1 protein in treatment of sepsis . World J Emerg Med . 2010 ; 1 : 93 - 8 .

Wang H , Bloom O , Zhang M , Vishnubhakat JM , Ombrellino M , Che J , et al . HMG-1 as a late mediator of endotoxin lethality in mice . Science . 1999 ; 285 : 248 - 51 .

Tracey KJ , Fong Y , Hesse DG , Manogue KR , Lee AT , Kuo GC , et al . Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia . Nature . 1987 ; 330 : 662 - 4 .

Chen G , Li J , Qiang X , Czura CJ , Ochani M , Ochani K , et al . Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis . J Lipid Res . 2005 ; 46 : 623 - 7 .

Bonaldi T , Talamo F , Scaffidi P , Ferrera D , Porto A , Bachi A , et al . Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion . EMBO J . 2003 ; 22 : 5551 - 60 .

Kang R , Chen R , Zhang Q , Hou W , Wu S , Cao L , et al . HMGB1 in health and disease . Mol Aspects Med . 2014 ; 40 : 1 - 116 .

Bustin M . At the crossroads of necrosis and apoptosis: signaling to multiple cellular targets by HMGB1 . Sci STKE . 2002 ; 2002 : E39 .

Yanai H , Matsuda A , An J , Koshiba R , Nishio J , Negishi H , et al . Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection . Proc Natl Acad Sci U S A . 2013 ; 110 : 20699 - 704 .

Kang R , Zhang Q , Hou W , Yan Z , Chen R , Bonaroti J , et al . Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice . Gastroenterology . 2014 ; 146 : 1097 - 107 .

Huang H , Nace GW , McDonald KA , Tai S , Klune JR , Rosborough BR , et al . Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection . Hepatology . 2014 ; 59 : 1984 - 97 .

Lu B , Wang C , Wang M , Li W , Chen F , Tracey KJ , et al . Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review . Expert Rev Clin Immunol . 2014 ; 10 : 713 - 27 .

Ivanov S , Dragoi AM , Wang X , Dallacosta C , Louten J , Musco G , et al . A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA . Blood . 2007 ; 110 : 1970 - 81 .

Rendon-Mitchell B , Ochani M , Li J , Han J , Wang H , Yang H , et al . IFN-gamma Induces High Mobility Group Box 1 Protein Release Partly Through a TNF-Dependent Mechanism . J Immunol . 2003 ; 170 : 3890 - 7 .

Kim JH , Kim SJ , Lee IS , Lee MS , Uematsu S , Akira S , et al . Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway . J Immunol . 2009 ; 182 : 2458 - 66 .

Qiang X , Yang WL , Wu R , Zhou M , Jacob A , Dong W , et al . Cold-inducible RNA-binding protein CIRP triggers inflammatory responses in hemorrhagic shock and sepsis . Nat Med . 2013 ; 19 : 1489 - 95 .

Lu B , Antoine DJ , Kwan K , Lundback P , Wahamaa H , Schierbeck H , et al . JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation . Proc Natl Acad Sci U S A . 2014 ; 111 : 3068 - 73 .

Youn JH , Shin JS . Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion . J Immunol . 2006 ; 177 : 7889 - 97 .

Wang H , Ward MF , Sama AE . Targeting HMGB1 in the treatment of sepsis . Expert Opin Ther Targets . 2014 ; 18 : 257 - 68 .

Gardella S , Andrei C , Ferrera D , Lotti LV , Torrisi MR , Bianchi ME , et al . The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway . EMBO Rep . 2002 ; 3 : 955 - 1001 .

Ohmori Y , Hamilton TA . Requirement for STAT1 in LPS-induced gene expression in macrophages . J Leukoc Biol . 2001 ; 69 : 598 - 604 .

Qin S , Wang H , Yuan R , Li H , Ochani M , Ochani K , et al . Role of HMGB1 in apoptosis-mediated sepsis lethality . J Exp Med . 2006 ; 203 : 1637 - 42 .

Lamkanfi M , Sarkar A , Vande WL , Vitari AC , Amer AO , Wewers MD , et al . Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia . J Immunol . 2010 ; 185 : 4385 - 92 .

Lu B , Nakamura T , Inouye K , Li J , Tang Y , Lundback P , et al . Novel role of PKR in inflammasome activation and HMGB1 release . Nature . 2012 ; 488 : 670 - 4 .

Hett EC , Slater LH , Mark KG , Kawate T , Monks BG , Stutz A , et al . Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis . Nat Chem Biol . 2013 ; 9 : 398 - 405 .

Thapa RJ , Nogusa S , Chen P , Maki JL , Lerro A , Andrake M , et al . Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases . Proc Natl Acad Sci U S A . 2013 ; 110 : E3109 - 18 .

Scaffidi P , Misteli T , Bianchi ME . Release of chromatin protein HMGB1 by necrotic cells triggers inflammation . Nature . 2002 ; 418 : 191 - 5 .

Tsung A , Sahai R , Tanaka H , Nakao A , Fink MP , Lotze MT , et al . The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemiareperfusion . J Exp Med . 2005 ; 201 : 1135 - 43 .

Andrassy M , Volz HC , Igwe JC , Funke B , Eichberger SN , Kaya Z , et al . Highmobility group box-1 in ischemia-reperfusion injury of the heart . Circulation . 2008 ; 117 : 3216 - 26 .

Cohen MJ , Brohi K , Calfee CS , Rahn P , Chesebro BB , Christiaans SC , et al . Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion . Crit Care . 2009 ; 13 : R174 . doi: 10.1186/cc8152 http://doi.org/10.1186/cc8152 .

Peltz ED , Moore EE , Eckels PC , Damle SS , Tsuruta Y , Johnson JL , et al . HMGB1 is markedly elevated within 6 h of mechanical trauma in humans . Shock . 2009 ; 32 : 17 - 22 .

Zhou RR , Liu HB , Peng JP , Huang Y , Li N , Xiao MF , et al . High mobility group box chromosomal protein 1 in acute-on-chronic liver failure patients and mice with ConA-induced acute liver injury . Exp Mol Pathol . 2012 ; 93 : 213 - 9 .

Antoine DJ , Dear JW , Lewis PS , Platt V , Coyle J , Masson M , et al . Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital . Hepatology . 2013 ; 58 : 777 - 87 .

Seo YS , Kwon JH , Yaqoob U , Yang L , de Assuncao TM , Simonetto DA , et al . HMGB1 recruits hepatic stellate cells and liver endothelial cells to sites of ethanol induced parenchymal cell injury . Am J Physiol Gastrointest Liver Physiol . 2013 ; 305 : G838 - 48 .

Chen LC , Yeh TM , Wu HN , Lin YY , Shyu HW . Dengue virus infection induces passive release of high mobility group box 1 protein by epithelial cells . J Infect . 2008 ; 56 : 143 - 50 .

Whilding LM , Archibald KM , Kulbe H , Balkwill FR , Oberg D , McNeish IA . Vaccinia Virus Induces Programmed Necrosis in Ovarian Cancer Cells . Mol Ther . 2013 ; 21 : 2074 .

Cho YS , Challa S , Moquin D , Genga R , Ray TD , Guildford M , et al . Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation . Cell . 2009 ; 137 : 1112 - 23 .

Xu J , Jiang Y , Wang J , Shi X , Liu Q , Liu Z , et al . Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis . Cell Death Differ . 2014 ; 21 : 1229 - 39 .

Andersson U , Tracey KJ . HMGB1 is a therapeutic target for sterile inflammation and infection . Annu Rev Immunol . 2011 ; 29 : 139 - 62 .

Zhang Q , Raoof M , Chen Y , Sumi Y , Sursal T , Junger W , et al . Circulating mitochondrial DAMPs cause inflammatory responses to injury . Nature . 2010 ; 464 : 104 - 7 .

Tian J , Avalos AM , Mao SY , Chen B , Senthil K , Wu H , et al . Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE . Nat Immunol . 2007 ; 8 : 487 - 96 .

Venereau E , Casalgrandi M , Schiraldi M , Antoine DJ , Cattaneo A , De Marchis F , et al . Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release . J Exp Med . 2012 ; 209 : 1519 - 28 .

Yang H , Lundback P , Ottosson L , Erlandsson-Harris H , Venereau E , Bianchi ME , et al . Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 HMGB1 . Mol Med . 2012 ; 18 : 250 - 9 . doi: 10.2119/molmed.2011.00389 http://doi.org/10.2119/molmed.2011.00389 .

Schiraldi M , Raucci A , Munoz LM , Livoti E , Celona B , Venereau E , et al . HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4 . J Exp Med . 2012 ; 209 : 551 - 63 .

Yang D , Chen Q , Yang H , Tracey KJ , Bustin M , Oppenheim JJ . High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin . J Leukoc Biol . 2007 ; 81 : 59 - 66 .

Dumitriu IE , Bianchi ME , Bacci M , Manfredi AA , Rovere-Querini P . The secretion of HMGB1 is required for the migration of maturing dendritic cells . J Leukoc Biol . 2007 ; 81 : 84 - 91 .

Orlova VV , Choi EY , Xie C , Chavakis E , Bierhaus A , Ihanus E , et al . A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin . EMBO J . 2007 ; 26 : 1129 - 39 .

Degryse B , Bonaldi T , Scaffidi P , Muller S , Resnati M , Sanvito F , et al . The high mobility group HMG boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells . J Cell Biol . 2001 ; 152 : 1197 - 206 .

Degryse B , de Virgilio M . The nuclear protein HMGB1, a new kind of chemokine? FEBS Lett . 2003 ; 553 : 11 - 7 .

Yu M , Wang H , Ding A , Golenbock DT , Latz E , Czura CJ , et al . HMGB1 signals through Toll-like receptor TLR4 and TLR2 . Shock . 2006 ; 26 : 174 - 9 .

Ha T , Xia Y , Liu X , Lu C , Liu L , Kelley J , et al . Glucan phosphate attenuates myocardial HMGB1 translocation in severe sepsis through inhibiting NF-kappaB activation . Am J Physiol Heart Circ Physiol . 2011 ; 301 : H848 - 55 .

Xiang M , Shi X , Li Y , Xu J , Yin L , Xiao G , et al . Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells . J Immunol . 2011 ; 187 : 4809 - 17 .

Chen GY , Tang J , Zheng P , Liu Y . CD24 and Siglec-10 selectively repress tissue damage-induced immune responses . Science . 2009 ; 323 : 1722 - 5 .

Abeyama K , Stern DM , Ito Y , Kawahara K , Yoshimoto Y , Tanaka M , et al . The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism . J Clin Invest . 2005 ; 115 : 1267 - 74 .

Salmivirta M , Rauvala H , Elenius K , Jalkanen M . Neurite growth-promoting protein amphoterin, p30 binds syndecan . Exp Cell Res . 1992 ; 200 : 444 - 51 .

Yang H , Ochani M , Li J , Qiang X , Tanovic M , Harris HE , et al . Reversing established sepsis with antagonists of endogenous high-mobility group box 1 . Proc Natl Acad Sci U S A . 2004 ; 101 : 296 - 301 .

Wang H , Yang H , Czura CJ , Sama AE , Tracey KJ . HMGB1 as a Late Mediator of Lethal Systemic Inflammation . Am J Respir Crit Care Med . 2001 ; 164 : 1768 - 73 .

Abraham E , Arcaroli J , Carmody A , Wang H , Tracey KJ . HMG-1 as a mediator of acute lung inflammation . J Immunol . 2000 ; 165 : 2950 - 4 .

Suda K , Kitagawa Y , Ozawa S , Saikawa Y , Ueda M , Ebina M , et al . Anti-highmobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis . World J Surg . 2006 ; 30 : 1755 - 62 .

Ye C , Choi JG , Abraham S , Wu H , Diaz D , Terreros D , et al . Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model . Proc Natl Acad Sci U S A . 2012 ; 109 : 21052 - 7 .

Wang H , Liao H , Ochani M , Justiniani M , Lin X , Yang L , et al . Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis . Nat Med . 2004 ; 10 : 1216 - 21 .

Li W , Ashok M , Li J , Yang H , Sama AE , Wang H . A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1 . PLoS One . 2007 ; 2 : e1153 .

Li W , Li J , Ashok M , Wu R , Chen D , Yang L , et al . A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1 . J Immunol . 2007 ; 178 : 3856 - 64 .

Valdes-Ferrer SI , Rosas-Ballina M , Olofsson PS , Lu B , Dancho ME , Li J , et al . High-mobility group box 1 mediates persistent splenocyte priming in sepsis survivors: evidence from a murine model . Shock . 2013 ; 40 : 492 - 5 .

Sursal T , Stearns-Kurosawa DJ , Itagaki K , Oh SY , Sun S , Kurosawa S , et al . Plasma bacterial and mitochondrial DNA distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates . Shock . 2013 ; 39 : 55 - 62 .

Vincent JL , Opal SM , Marshall JC , Tracey KJ . Sepsis definitions: time for change . Lancet . 2013 ; 381 : 774 - 5 .

Zhu S , Li W , Ward MF , Sama AE , Wang H . High mobility group box 1 protein as a potential drug target for infection- and injury-elicited inflammation . Inflamm Allergy Drug Targets . 2010 ; 9 : 60 - 72 .

Wu H , Ma J , Wang P , Corpuz TM , Panchapakesan U , Wyburn KR , et al . HMGB1 contributes to kidney ischemia reperfusion injury . J Am Soc Nephrol . 2010 ; 21 : 1878 - 90 .

Qiu J , Nishimura M , Wang Y , Sims JR , Qiu S , Savitz SI , et al . Early release of HMGB-1 from neurons after the onset of brain ischemia . J Cereb Blood Flow Metab . 2008 ; 28 : 927 - 38 .

Okuma Y , Liu K , Wake H , Zhang J , Maruo T , Date I , et al . Anti-high mobility group box-1 antibody therapy for traumatic brain injury . Ann Neurol . 2012 ; 72 : 373 - 84 .

Shimazaki J , Matsumoto N , Ogura H , Muroya T , Kuwagata Y , Nakagawa J , et al . Systemic involvement of high-mobility group box 1 protein and therapeutic effect of anti-high-mobility group box 1 protein antibody in a rat model of crush injury . Shock . 2012 ; 37 : 634 - 8 .

Yang R , Zhang S , Cotoia A , Oksala N , Zhu S , Tenhunen J . High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity . BMC Gastroenterol . 2012 ; 12 : 45 . doi: 10.1186/1471-230X-12-45 http://doi.org/10.1186/1471-230X-12-45 .

Nadatani Y , Watanabe T , Tanigawa T , Machida H , Okazaki H , Yamagami H , et al . High mobility group box 1 promotes small intestinal damage induced by nonsteroidal anti-inflammatory drugs through Toll-like receptor 4 . Am J Pathol . 2012 ; 181 : 98 - 110 .

Hirata Y , Kurobe H , Higashida M , Fukuda D , Shimabukuro M , Tanaka K , et al . HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9 . Atherosclerosis . 2013 ; 231 : 227 - 33 .

Nadatani Y , Watanabe T , Tanigawa T , Ohkawa F , Takeda S , Higashimori A , et al . High-mobility group box 1 inhibits gastric ulcer healing through Toll-like receptor 4 and receptor for advanced glycation end products . PLoS One . 2013 ; 8 : e80130 .

Patel VS , Sitapara RA , Gore A , Phan B , Sharma L , Sampat V , et al . High Mobility Group Box-1 mediates hyperoxia-induced impairment of Pseudomonas aeruginosa clearance and inflammatory lung injury in mice . Am J Respir Cell Mol Biol . 2013 ; 48 : 280 - 7 .

Wu A , He L , Long W , Zhou Q , Zhu S , Wang P , et al . Novel mechanisms of herbal therapies for inhibiting HMGB1 secretion or action . Evid Based Complement Alternat Med . 2015 ; 2015 : 456305 .

Wang H , Li W , Li J , Rendon-Mitchell B , Ochani M , Ashok M , et al . The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis , protects mice against lethal endotoxemia and sepsis . J Nutr . 2006 ; 136 : 360 - 5 .

Zhu S , Li W , Li J , Jundoria A , Sama AE , Wang H . It is not just folklore: the aqueous extract of mung bean coat is protective against sepsis . Evid Based Complement Alternat Med . 2012 ; 2012 : 498467 . doi: 10.1155/2012/498467 http://doi.org/10.1155/2012/498467 .

Okamoto T , Kanda T . Glycyrrhizin protects mice from concanavalin A-induced hepatitis without affecting cytokine expression . Int J Mol Med . 1999 ; 4 : 149 - 52 .

Mabuchi A , Wake K , Marlini M , Watanabe H , Wheatley AM . Protection by glycyrrhizin against warm ischemia-reperfusion-induced cellular injury and derangement of the microcirculatory blood flow in the rat liver . Microcirculation . 2009 ; 16 : 364 - 76 .

Ogiku M , Kono H , Hara M , Tsuchiya M , Fujii H . Glycyrrhizin prevents liver injury by inhibition of high-mobility group box 1 production by Kupffer cells after ischemia-reperfusion in rats . J Pharmacol Exp Ther . 2011 ; 339 : 93 - 8 .

Kuroda N , Inoue K , Ikeda T , Hara Y , Wake K , Sato T . Apoptotic response through a high mobility box 1 protein-dependent mechanism in LPS/GalN-induced mouse liver failure and glycyrrhizin-mediated inhibition . PLoS One . 2014 ; 9 : e92884 .

Wang X , Sun R , Wei H , Tian Z . High-mobility group box 1 HMGB1-Toll-like receptor TLR4-interleukin IL-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: Interaction of gammadelta T cells with macrophages . Hepatology . 2013 ; 57 : 373 - 84 .

Sakamoto R , Okano M , Takena H , Ohtsuki K . Inhibitory effect of glycyrrhizin on the phosphorylation and DNA-binding abilities of high mobility group proteins 1 and 2 in vitro . Biol Pharm Bull . 2001 ; 24 : 906 - 11 .

Mollica L , De Marchis F , Spitaleri A , Dallacosta C , Pennacchini D , Zamai M , et al . Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities . Chem Biol . 2007 ; 14 : 431 - 41 .

Yamaguchi H , Kidachi Y , Kamiie K , Noshita T , Umetsu H . Structural insight into the ligand-receptor interaction between glycyrrhetinic acid GA and the high-mobility group protein B1 HMGB1-DNA complex . Bioinformation . 2012 ; 8 : 1147 - 53 .

Shearman DJ , Hetzel D . The medical management of peptic ulcer . Annu Rev Med . 1979 ; 30 : 61 - 79 .

Ma W , Hui H , Pelegrin P , Surprenant A . Pharmacological characterization of pannexin-1 currents expressed in mammalian cells . J Pharmacol Exp Ther . 2009 ; 328 : 409 - 18 .

Poornima V , Madhupriya M , Kootar S , Sujatha G , Kumar A , Bera AK . P2X7 receptor-pannexin 1 hemichannel association: effect of extracellular calcium on membrane permeabilization . J Mol Neurosci . 2012 ; 46 : 585 - 94 .

Li W , Li J , Sama AE , Wang H . Carbenoxolone blocks endotoxin-induced protein kinase R(PKR) activation and high mobility group box 1(HMGB1) Release . Mol Med . 2013 ; 19 : 203 - 11 .

Thompson RJ , Zhou N , MacVicar BA . Ischemia opens neuronal gap junction hemichannels . Science . 2006 ; 312 : 924 - 7 .

Reigada D , Lu W , Zhang M , Mitchell CH . Elevated pressure triggers a physiological release of ATP from the retina: Possible role for pannexin hemichannels . Neuroscience . 2008 ; 157 : 396 - 404 .

Sridharan M , Adderley SP , Bowles EA , Egan TM , Stephenson AH , Ellsworth ML , et al . Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes . Am J Physiol Heart Circ Physiol . 2010 ; 299 : H1146 - 52 .

Surprenant A , Rassendren F , Kawashima E , North RA , Buell G . The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor P2X7 . Science . 1996 ; 272 : 735 - 8 .

Perregaux DG , McNiff P , Laliberte R , Conklyn M , Gabel CA . ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood . J Immunol . 2000 ; 165 : 4615 - 23 .

Li W , Zhu S , Li J , Assa A , Jundoria A , Xu J , et al . EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages . Biochem Pharmacol . 2011 ; 81 : 1152 - 63 .

Zhou J , Farah BL , Sinha RA , Wu Y , Singh BK , Bay BH , et al . Epigallocatechin-3-gallate EGCG, a green tea polyphenol, stimulates hepatic autophagy and lipid clearance . PLoS One . 2014 ; 9 : e87161 .

Li CP , Yao J , Tao ZF , Li XM , Jiang Q , Yan B . Epigallocatechin-gallate EGCG regulates autophagy in human retinal pigment epithelial cells: a potential role for reducing UVB light-induced retinal damage . Biochem Biophys Res Commun . 2013 ; 438 : 739 - 45 .

Kim HS , Montana V , Jang HJ , Parpura V , Kim JA . Epigallocatechin gallate EGCG stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation . J Biol Chem . 2013 ; 288 : 22693 - 705 .

Tang D , Kang R , Livesey KM , Cheh CW , Farkas A , Loughran P , et al . Endogenous HMGB1 regulates autophagy . J Cell Biol . 2010 ; 190 : 881 - 92 .

Kang R , Livesey KM , Zeh HJ , Loze MT , Tang D . HMGB1: A novel Beclin 1-binding protein active in autophagy . Autophagy . 2010 ; 6 : 1209 - 11 .

Zhang Y , Li W , Zhu S , Jundoria A , Li J , Yang H , et al . Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake . Biochem Pharmacol . 2012 ; 84 : 1492 - 500 .

Gordon PB , Seglen PO . Prelysosomal convergence of autophagic and endocytic pathways . Biochem Biophys Res Commun . 1988 ; 151 : 40 - 7 .

Klionsky DJ . Autophagy: from phenomenology to molecular understanding in less than a decade . Nat Rev Mol Cell Biol . 2007 ; 8 : 931 - 7 .

Berg TO , Fengsrud M , Stromhaug PE , Berg T , Seglen PO . Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes . J Biol Chem . 1998 ; 273 : 21883 - 92 .

Lefering R , Neugebauer EA . Steroid controversy in sepsis and septic shock: a meta-analysis . Crit Care Med . 1995 ; 23 : 1294 - 303 .

Annane D , Sebille V , Charpentier C , Bollaert PE , Francois B , Korach JM , et al . Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock . JAMA . 2002 ; 288 : 862 - 71 .

Sprung CL , Annane D , Keh D , Moreno R , Singer M , Freivogel K , et al . Hydrocortisone therapy for patients with septic shock . N Engl J Med . 2008 ; 358 : 111 - 4 .

Rivers E , Nguyen B , Havstad S , Ressler J , Muzzin A , Knoblich B , et al . Early goal-directed therapy in the treatment of severe sepsis and septic shock . N Engl J Med . 2001 ; 345 : 1368 - 77 .

Russell JA , Walley KR , Singer J , Gordon AC , Hebert PC , Cooper DJ , et al . Vasopressin versus norepinephrine infusion in patients with septic shock . N Engl J Med . 2008 ; 358 : 877 - 87 .

Zhao L , Li W , Zhu S , Tsai S , Li J , Tracey KJ , et al . Green tea catechins quench the fluorescence of bacteria-conjugated Alexa fluor dyes . Inflamm Allergy Drug Targets . 2013 ; 12 : 308 - 14 .

He XD , Wang Y , Wu Q , Wang HX , Chen ZD , Zheng RS , et al . Xuebijing protects rats from sepsis challenged with Acinetobacter baumannii by promoting annexin A1 expression and inhibiting proinflammatory cytokines secretion . Evid Based Complement Alternat Med . 2013 ; 2013 : 804940 . doi: 10.1155/2013/804940 http://doi.org/10.1155/2013/804940 .

Yin Q , Li C . Treatment effects of xuebijing injection in severe septic patients with disseminated intravascular coagulation . Evid Based Complement Alternat Med . 2014 ; 2014 : 949254 . doi: 10.1155/2014/949254 http://doi.org/10.1155/2014/949254 .

Qi F , Liang ZX , She DY , Yan GT , Chen LA . A clinical study on the effects and mechanism of xuebijing injection in severe pneumonia patients . J Tradit Chin Med . 2011 ; 31 : 46 - 9 .

Nakahira K , Haspel JA , Rathinam VA , Lee SJ , Dolinay T , Lam HC , et al . Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome . Nat Immunol . 2011 ; 12 : 222 - 30 .

Shi CS , Shenderov K , Huang NN , Kabat J , Abu-Asab M , Fitzgerald KA , et al . Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction . Nat Immunol . 2012 ; 13 : 255 - 63 .

Ziegler EJ , Fisher Jr CJ , Sprung CL , Straube RC , Sadoff JC , Foulke GE , et al . Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group . N Engl J Med . 1991 ; 324 : 429 - 36 .

Opal SM , Laterre PF , Francois B , LaRosa SP , Angus DC , Mira JP , et al . Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial . JAMA . 2013 ; 309 : 1154 - 62 .

Feldmann M , Maini RN . Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol . 2001 ; 19 : 163 - 96 .

Weber GF , Chousterman BG , He S , Fenn AM , Nairz M , Anzai A , et al . Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis . Science . 2015 ; 347 : 1260 - 5 .

Yang H , Wang H , Ju Z , Ragab AA , Lundbäck P , Long W , et al . MD-2 is required for disulfide HMGB1-dependent TLR4 signaling . J Exp Med . 2015 ; 212 : 5 - 14 .

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