Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity

Hui Wang; Rui-Yun Peng

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Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity

REVIEW | Updated：2022-12-27

- Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity
- Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity
- 解放军医学杂志（英文版） 2016年3卷第4期页码：212-218
- Affiliations：
  
  Department of Experimental Pathology,Beijing Institute of Radiation Medicine
- Author bio：
- Funds：
  
  supported by the National Natural Science Foundation of China（61401497）
- DOI：
  中图分类号： R338
- 纸质出版：2016
- Accepted：
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Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity[J]. 解放军医学杂志（英文版）, 2016,3(4):212-218.

[1]Hui Wang,Rui-Yun Peng.Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity[J].Military Medical Research,2016,3(04):212-218.
Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity[J]. 解放军医学杂志（英文版）, 2016,3(4):212-218. DOI：

[1]Hui Wang,Rui-Yun Peng.Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity[J].Military Medical Research,2016,3(04):212-218. DOI：

摘要

Abstract

With key roles in essential brain functions ranging from the long-term potentiation（LTP） to synaptic plasticity

the N-methyl-D-aspartic acid receptor（NMDAR） can be considered as one of the fundamental glutamate receptors in the central nervous system.The role of NMDA R was first identified in synaptic plasticity and has been extensively studied.Some molecules

such as Ca

postsynaptic density 95（PSD-95）

calcium/calmodulin-dependent protein kinase II（Ca MK II）

protein kinase A（PKA）

mitogen-activated protein kinase（MAPK） and cyclic adenosine monophosphate（c AMP） responsive element binding protein（CREB）

are of special importance in learning and memory.This review mainly focused on the new research of key molecules connected with learning and memory

which played important roles in the NMDAR signaling pathway.

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