Effects of microwave radiation on brain energy metabolism and related mechanisms

Yan-Hui Hao; Li Zhao; Rui-Yun Peng

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Effects of microwave radiation on brain energy metabolism and related mechanisms

REVIEW | Updated：2022-12-27

- Effects of microwave radiation on brain energy metabolism and related mechanisms
- Effects of microwave radiation on brain energy metabolism and related mechanisms
- MMR 2014年1卷第4期页码：235-243
- Affiliations：
  
  Beijing Institute of Radiation Medicine, Beijing 100850, China
- Author bio：
  
  Li Zhao, lillyliz@163.com
  *: Rui-Yun Peng, ruiyunpeng18@126.com;
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2014-12
- Accepted：
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Effects of microwave radiation on brain energy metabolism and related mechanisms[J]. MMR, 2014,1(4):235-243.

Hao et al.: Effects of microwave radiation on brain energy metabolism and related mechanisms. Mil Med Res 2014
Effects of microwave radiation on brain energy metabolism and related mechanisms[J]. MMR, 2014,1(4):235-243. DOI：

Hao et al.: Effects of microwave radiation on brain energy metabolism and related mechanisms. Mil Med Res 2014 DOI：

摘要

Abstract

With the rapid development of electronic technologies

anxiety regarding the potential health hazards induced by microwave radiation (MW) has been growing in recent years. The brain is one of the most sensitive target organs for microwave radiation

where mitochondrial injury occurs earlier and more severely than in other organs. Energy metabolism disorders do play an important role during the process of microwave radiation-induced brain damage. In this paper

we will review the biological effects of microwave radiation

the features of brain energy supply and consumption and the effects of microwave radiation on mitochondrial energy metabolism and potential related mechanisms.

关键词

Keywords

references

Röösli M , Rapp R , Braun-Fahrländer C : Radio and microwave frequency radiation and health--an analysis of the literature . Gesundheitswesen 2003 , 65 : 378 - 392 .

Adair ER , Black DR : Thermoregulatory responses to RF energy absorption . Bioelectromagnetics 2003 , 24 : S17 - S38 .

Black DR , Heynick LN : Radiofrequency (RF) effects on blood cells, cardiac, endocrine, and immunological functions . Bioelectromagnetics 2003 , 24 : S187 - S195 .

Cao GF , Tong J , Wang J , Liu Q , Jin YL : Study on Effect of Weak Radio-frequency Electomagnetic Field on Neurobehavioral of Human and Mice . Ind Hlth & Occup Dis 2004 , 30 : 135 - 137 .

Zhao L , Peng RY , Wang SM , Wang LF , Gao YB , Dong J , Li X , Su ZT : Relationship between cognition function and hippocampus structure after long-term microwave exposure . Biomed Environ Sci 2012 , 25 : 182 - 188 .

Hu SH , Peng RY , Wang SM , Gao YB , Dong J , Xu XP , Zhao L , Yao BW , Zhang XY , Zhou HM , Su ZT : Ptotective effects of Kang Fu Ling on brian injury induced by microwave radiation in rats . Chin J Stereol Image Anal 2013 , 18 : 48 - 54 .

Ren JH , Peng RY , Zhang J , Li J , Gao YB , Wang SM , Dong J , Zuo HY , Su ZT , Zhou HM : Prevention effects of AduoLa Fuzhenglin on brian injury induced by microwave radiation in rats . Chin J Radio Med Prot 2011 , 31 : 190 - 193 .

Lv SJ , Tian ZJ , Jiang YX , Wang C , Lu XJ , Pan WG : Effects of high power pulsed microwave radiation on brain structure and function in rats . Chin J Public Health 2009 , 25 : 177 - 178 .

Zhong XH , Xu JJ , Liu HM , Jiang YX , Lu XJ , Lv Sj : Morphological changes of heart and liver induced by high power microwave HPM radiation in rats . Chin J Public Health 2010 , 26 : 1559 - 1560 .

Esmekaya MA , Aytekin E , Ozgur E , Güler G , Ergun MA , Omeroğlu S , Seyhan N : Mutagenic and morphologic impacts of 1.8GHz radiofrequency radiation on human peripheral blood lymphocytes (hPBLs) and possible protective role of pre-treatment with Ginkgo biloba (EGb 761) . Sci Total Environ 2011 , 410-411 : 59 - 64 .

Ma Q , Du L , Cui YF , Guo Y , Sun R , Dong B , Su ZT , Zhou DM , Liu XL , Xie L , Pan XJ : Effects of 5mW/cm2 microwave irradiation with different pulse widths on human AHH-1 T lymphocytes . Med J Chin PLA 2010 , 35 : 1311 - 1314 .

Hu HX , Fang H , Luo SB , Dong J , Wei LZ : Effects of microwave radiaiton on the ultrastructure of sperm head and tail of radar-operators . Chin J Androl 2010 , 24 : 33 - 35 .

Shahin S , Singh VP , Shukla RK , Dhawan A , Gangwar RK , Singh SP , Chaturvedi CM : 2.45 GHz microwave irradiation-induced oxidative stress affects implantation or pregnancy in mice, Mus musculus . Appl Biochem Biotechnol 2013 , 169 : 1727 - 1751 .

Yao BW , Peng RY , Wang SM , Gao YB , Dong J , Xu XP , Zhang J , Hu SH , Zhang XY , Wang H , Sun CF : Preventive and therapeutic effects of a traditional Chinese medicine “Kang Fu Ling” on the sperm injury in rats induced . Chin J Stereol Image Anal 2012 , 17 : 149 - 155 .

Guo S , Wang X , Xu J , Lei J , Sun K , Jiang X , Xu H , Lu S : Effect of microwave radiation on the rat hematopoietic system . J Hyg Res 2011 , 40 : 223 - 226 .

Balduini W , Carloni S , Buonocore G : Autophagy in hypoxia-ischemia induced brain injury . J Matern Fetal Neonatal Med 2012 , 1 : 30 - 34 .

Greene-Schloesser D , Robbins ME , Peiffer AM , Shaw EG , Wheeler KT , Chan MD : Radiation-induced brain injury: A review . Front Oncol 2012 , 2 : 73 .

Wang H , Peng R , Zhou H , Wang S , Gao Y , Wang L , Yong Z , Zuo H , Zhao L , Dong J , Xu X , Su Z : Impairment of long-term potentiation induction is essential for the disruption of spatial memory after microwave exposure . Int J Radiat Biol 2013 , 89 : 1100 - 1107 .

Xu S , Ning W , Xu Z , Zhou S , Chiang H , Luo J : Chronic exposure to GSM 1800MHz microwaves reduces excitatory synaptic activity in cultured hippocampal neurons . Neurosci Lett 2006 , 398 : 253 - 257 .

Jauchem JR : A literature review of medical side effects from radio-frequency energy in the human environment: involving cancer, tumors, and problems of the central nervous system . J Microw Power Electromagn Energy 2003 , 38 : 103 - 123 .

Dong J , Peng RY , Wang SM , Gao YB , Wang LF , Zhao L , Li Y , Xu XP , Yao BW : Effects on abilities of learning and memory and structural changes of brain in rats induced by microwave radiation under different conditions . Mil Med Sci 2011 , 35 : 347 - 350 .

Deshmukh PS , Banerjee BD , Abegaonkar MP , Megha K , Ahmed RS , Tripathi AK , Mediratta PK : Effect of low level microwave radiation exposure on cognitive function and oxidative stress in rats . Indian J Biochem Biophys 2013 , 50 : 114 - 119 .

Ma D , Peng RY , Gao YB , Wang SM , Zhao L , Wang SX , Wang XM , Xu XP , Xu TH : Effects of microwave radiation on structure and energy metabolism in rat hippocampus . Chin J Stereol Image Anal 2010 , 15 : 420 - 424 .

Zhao L , Yang YF , Gao YB , Wang SM , Wang LF , Zuo HY , Dong J , Xu XP , Su ZT , Zhou HM : Upregulation of HIF-1α via activation of ERK and PI3K pathway mediated protective response to microwave-induced mitochondrial injury in neuron-like cells . Mol Neurobiol 2014 , 50 : 1024 - 1034 .

Zhao L , Peng RY , Gao YB , Wang SM , Wang LF , Dong J , Xu XP , Ma JJ : Mitchondria morphologic changes and metabolic effects of rat hippocampus after microwave irradiation . Chin J Radiol Med Prot 2007 , 27 : 602 - 604 .

Wang LF , Li X , Peng RY , Gao YB , Zhao L , Wang SM , Xu XP , Dong J , Li Y , Wang SX : A metabolomic approach to screening urinary metabolites upon microwave exposure in monkeys . Mil Med Sci 2011 , 35 : 369-374, 378 .

Xie Y , Jiang HH , Gong XF , Zhuang GB , Yu JH , Yu ZP : Effect of microwave irradiation on neurocyte mitochondrial ultrastructure and mtTFA mRNA expression in rats cerebral cortex and hippocampus . Chin J Ind Hyg Occup Dis 2004 , 22 : 28 - 31 .

Sanders AP , Joines WT : The effects of hyperthermia and hyperthermia plus microwaves on rat brain energy metabolism . Bioelectromagnetics 1984 , 5 : 63 - 70 .

Wang LF , Peng RY , Hu XJ , Gao YB , Ma JJ , Wang X , Wang SM , Hu WH , Wang DW , Yang Y : Studies on the influence of high power microwave radiation on energy metabolism of brian in rats . Chin J Radiol Health 2006 , 15 : 269 - 271 .

Correia SC , Santos RX , Perry G , Zhu X , Moreira PI , Smith MA : Mitochondria: the missing link between preconditioning and neuroprotection . J Alzheimers Dis 2010 , 20 : S475 - S485 .

Luques L , Shoham S , Weinstock M : Chronic brain cytochrome oxidase inhibition selectively alters hippocampal cholinergic innervation and impairs memory: prevention by ladostigil . Exp Neurol 2007 , 206 : 209 - 219 .

Mattson MP , Gleichmann M , Cheng A : Mitochondria in neuroplasticity and neurological disorders . Neuron 2008 , 60 : 748 - 766 .

Wang Q , Cao ZJ , Bai XT : Effect of microwave electromagnetic fields on activity of energy metabolism cytochrome oxidase in cerebral cortical neurons of postnatal rats . J Environ Health 2006 , 22 : 329 - 331 .

Xiong L , Peng RY , Gao YB , Wang SM , Wang LF , Dong J , Zhao L , Li Y , Zuo HY , Xu XP : Effects of AduoLa Fuzhenglin on changes of cytochrome c oxidase in rats' hippocampus after microwave exposure . Mil Med Sci 2011 , 35 : 333 - 337 .

Zhao L , Peng RY , Gao YB , Wang SM , Ma JJ , Wang LF , Su ZT , Yang GS : Screening for differentially expressed genes in rats' hippocampus after microwave radiation . Chin J Public Health 2007 , 23 : 1153 - 1155 .

Ongwijitwat S , Wong-Riley MT : Is nuclear respiratory factor 2 a master transcriptional coordinator for all ten nuclear-encoded cytochrome c oxidase subunits in neurons? Gene 2005 , 360 : 65 - 77 .

Chandrasekaran K , Hatanpää K , Rapoport SI , Brady DR : Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease . Brain Res Mol Brain Res 1997 , 44 : 99 - 104 .

Zhao L , Peng RY , Gao YB , Wang SM , Wang XM , Xu XP , Wang LF , Dong J : The changes of the COX gene expression in mitochondria in hippocampus of rats after exposure to microwave radiation . Chin J Phys Med Rehabil 2009 , 30 : 31 - 33 .

Xie Y , Jiang HH , Gong XF , Zhang GB , Lu B , Xu Q , Yu ZP : Effects of microwave irradiation on mitochondrial cytochrome C oxidase subunits mRNA in rat brain . Acta Academiae Medicinae Militaris Tertlae 2003 , 25 : 987 - 989 .

Ellis CE , Murphy EJ , Mitchell DC , Golovko MY , Scaglia F , Barcelo-Coblijn GC , Nussbaum RL : Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein . Mol Cell Biol 2005 , 25 : 10190 - 10201 .

Caubet R , Pedarros-Caubet F , Chu M , Freye E , De Belem Rodrigues M , Moreau JM , Ellison WJ : A radio frequency electric current enhances antibiotic efficacy against bacterial biofilms . Antimicrob Agents Chemother 2004 , 48 : 4662 - 4664 .

Wang Y , Sun HT , Wang BH , Zhang D : A study on thermal efficiency and non-thermal efficiency of microwave . Liaoning Chem Ind 2006 , 35 : 167 - 169 .

Kesari KK , Meena R , Nirala J , Kumar J , Verma HN : Effect of 3G cell phone exposure with computer controlled 2-D stepper motor on non-thermal activation of the hsp27/p38MAPK stress pathway in rat brain . Cell Biochem Biophys 2014 , 68 : 347 - 358 .

Kesari KK , Kumar S , Behari J : 900-MHz microwave radiation promotes oxidation in rat brain . Electromagn Biol Med 2011 , 30 : 219 - 234 .

Chen YM , Chen JY , Liu XH , Luo WJ , Wang Q , Xu H , Zheng G , Du KJ : Effects of complementary zinc on antioxidase in brian of rats irradiated by microwave . J Fourth Mil Med Univ 2005 , 26 : 444 - 446 .

Wang RY , Yang CL , Luo LH , Zhang JQ , Mu HL , Du P , Xin YM : Oxidative stress effect of microwave radiation on mice brian . J Prev Med Chin PLA 2013 , 31 : 292 - 294 .

Yang R , Peng RY , Gao YB , Wang SM , Hu WH , Xu XP , Su ZT , Hu XJ , Xu TH : The effect of microwaves on hippocampal neurons in vitro and its mechanism . Chin J Phys Med Rehabil 2006 , 28 : 670 - 673 .

Lu MX , Nie JH , Zhu JQ , Qian C , Wang GH , Tong J : Biological effects of 2450 MHz microwave combined with γ-rays on rat cultured gliacytes . J Radiat Res Raidat Process 2010 , 28 : 172 - 176 .

Whiteman M , Armstrong JS , Cheung NS , Siau JL , Rose P , Schantz JT , Jones DP , Halliwell B : Peroxynitrite mediates calcium-dependent mitochondrial dysfunction and cell death via activation of calpains . FASEB J 2004 , 18 : 1395 - 1397 .

Zuo HY , Lin T , Wang DW , Peng RY , Wang SM , Gao YB , Xu XP , Li Y , Wang SX , Zhao L : Neural cell apoptosis induced by microwave exposure through mitochondria-dependent caspase-3 pathway . Int J Med Sci 2014 , 11 : 426 - 435 .

Campisi A , Gulino M , Acquaviva R , Bellia P , Raciti G , Grasso R , Musumeci F , Vanella A , Triglia A : Reactive oxygen species levels and DNA fragmentation on astrocytes in primary culture after acute exposure to low intensity microwave electromagnetic field . Neurosci Lett 2010 , 473 : 52 - 55 .

Sokolovic D , Djindjic B , Nikolic J , Bjelakovic G , Pavlovic D , Kocic G , Krstic D , Cvetkovic T , Pavlovic V : Melatonin reduces oxidative stress induced by chronic exposure of microwave radiation from mobile phones in rat brain . J Radiat Res 2008 , 49 : 579 - 586 .

Ammari M , Lecomte A , Sakly M , Abdelmelek H , De-Seze R : Exposure to GSM 900 MHz electromagnetic fields affects cerebral cytochrome c oxidase activity . Toxicology 2008 , 250 : 70 - 74 .

Friedman J , Kraus S , Hauptman Y , Schiff Y , Seger R : Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies . Biochem J 2007 , 405 : 559 - 568 .

Tian ZJ , Shen N , Lv SJ , Wang C , Jiang YX , Luo J : The effects of Polysaccharides from Auricularia auricular on SOD in serum and lipid peroxidation in liver homogenate of rat by high power microwave radiation . Lishizhen Med Mater Med Res 2009 , 20 : 3011 - 3013 .

Wu ZY , Xu TH , Peng RY , Gao YB , Wang SM , Ma JJ , Wang XM , Hu WH , Xu XP , Su ZT , Wang LF , Zhao L , Wang X , Wang DW : The protective effect of GSH on injury to brian energy metabolism induced by HPM in rats . Chin J Stereol Image Anal 2006 , 11 : 127 - 130 .

Paulraj R , Behari J : Single strand DNA breaks in rat brain cells exposed to microwave radiation . Mutat Res 2006 , 596 : 76 - 80 .

Lai H , Singh NP : Magnetic-field-induced DNA strand breaks in brain cells of the rat . Environ Health Perspect 2004 , 112 : 687 - 694 .

Meena R , Kumari K , Kumar J , Rajamani P , Verma H , Kesari KK : Therapeutic approaches of melatonin in microwave radiations-induced oxidative stress-mediated toxicity on male fertility pattern of Wistar rats . Electromagn Biol Med 2014 , 33 : 81 - 91 .

Johnson GL , Lapadat R : Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases . Science 2002 , 298 : 1911 - 1912 .

Maher P , Schubert D : Signaling by reactive oxygen species in the nervous system . Cell Mol Life Sci 2000 , 57 : 1287 - 1305 .

Petronilli V , Penzo D , Scorrano L , Bernardi P , Di Lisa F : The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ . J Biol Chem 2001 , 276 : 12030 - 12034 .

Halestrap AP , Doran E , Gillespie JP , O'toole A : Mitochondria and cell death . Biochem Soc Trans 2000 , 28 : 170 - 177 .

Vaux DL : CED-4--the third horseman of apoptosis . Cell 1997 , 90 : 389 - 390 .

Golstein P : Controlling cell death . Science 1997 , 275 : 1081 - 1082 .

Kang D , Hamasaki N : Mitochondrial transcription factor A in the maintenance of mitochondrial DNA . Ann N Y Acad Sci 2005 , 1042 : 101 - 108 .

Li HX , Li CH : Apoptosis gene expression and their relationship to mtDNA mutation in tumor tissues of gynecologic oncology patients . Chin J Birth Health Hered 2003 , 11 : 34 - 36 .

Xu SC , Zhang L , Yu ZP , Zhong M : Effects of microwave exposure on Tfam expression in neurons and the relationship with energy metabolism disturbance . J Radiat Res Radiat Process 2008 , 26 : 305 - 308 .

Xu SC , Yu ZP , Wu J , Pei LP , Luo X , Chen CH , He MD , Wang Y , Yao Q , Zhong M : Inhibitory effect of microwave exposure on the import of mitochondrial transcription factor A (Tfam) . J Radiat Res Radiat Process 2009 , 27 : 173 - 176 .

Sheppard K , Kinross KM , Solomon B , Pearson RB , Phillips WA : Targeting PI3 kinase/AKT/mTOR signaling in cancer . Crit Rev Oncog 2012 , 17 : 69 - 95 .

Prasad SS , Russell M , Nowakowska M : Neuroprotection induced in vitro by ischemic preconditioning and postconditioning: modulation of apoptosis and PI3K-Akt pathways . J Mol Neurosci 2011 , 43 : 428 - 442 .

Fan X , Heijnen CJ , Van Der Kooij MA , Groenendaal F , Van Bel F : The role and regulation of hypoxia-inducible factor-1α expression in brain development and neonatal hypoxic–ischemic brain injury . Brain Res Rev 2009 , 62 : 99 - 108 .

Hu Q , Wu C , Chen J , Yan F , Li J , Chen G : The relationship between hypoxia-inducible factor-1α expression and apoptosis in early brain injury after subarachnoid hemorrhage . J Zhejiang Univ Med Sci 2014 , 43 : 58 - 65 .

Singh N , Sharma G , Mishra V , Raghubir R : Hypoxia inducible factor-1: Its potential role in cerebral ischemia . Cell Mol Neurobiol 2012 , 32 : 491 - 507 .

Li Y , Xia Z-L , Chen L-B : HIF-1-alpha and survivin involved in the anti-apoptotic effect of 2ME2 after global ischemia in rats . Neurol Res 2011 , 33 : 583 - 592 .

Ye Z , Guo Q , Xia P , Wang N , Wang E , Yuan Y : Sevoflurane postconditioning involves an up-regulation of HIF-1α and HO-1 expression via PI3K/Akt pathway in a rat model of focal cerebral ischemia . Brain Res 2012 , 1463 : 63 - 74 .

Xu J , Peng Z , Li R , Dou T , Xu W , Gu G , Liu Y , Kang Z , Tao H , Zhang JH , Ostrowski RP , Lu J , Sun X : Normoxic induction of cerebral HIF-1alpha by acetazolamide in rats: role of acidosis . Neurosci Lett 2009 , 451 : 274 - 278 .

Wang X , Hu XJ , Peng RY , Wang SM , Gao YB , Wang LF , Wu ZY , Wei L , Ma JJ , Hu WH , Su ZT : Expression and significance of hypoxia inducible factor-1 alpha in rat brain after HPM exposure . Chin J Public Health 2007 , 23 : 1161 - 1163 .

Zhao L , Peng RY , Gao YB , Wang SM , Wang LF , Dong J , Xu XP , Su ZT : Activation of HIF-1α/ERK pathway regulates the injury of neuron mitochondria in hippocampus induced by long-term microwave exposure . SCIENTIA SINICA Vitae 2011 , 41 : 945 - 950 .

Bickler PE , Donohoe PH : Adaptive responses of vertebrate neurons to hypoxia . J Exp Biol 2002 , 205 : 3579 - 3586 .

Choi SY , Kim MJ , Kang CM , Bae S , Cho CK , Soh JW , Kim JH , Kang S , Chung HY , Lee YS : Activation of Bak and Bax through c-abl-protein kinase Cdelta-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells . J Biol Chem 2006 , 281 : 7049 - 7059 .

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