Dramatic resolution of vitreous hemorrhage after an intravitreal injection of dobesilate

Pedro Cuevas; Luis Antonio Outeiriño; Carlos Azanza; Javier Angulo; Guillermo Giménez-Gallego

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Dramatic resolution of vitreous hemorrhage after an intravitreal injection of dobesilate

CASE REPORT | Updated：2022-12-27

- Dramatic resolution of vitreous hemorrhage after an intravitreal injection of dobesilate
- Dramatic resolution of vitreous hemorrhage after an intravitreal injection of dobesilate
- MMR 2015年2卷第3期页码：163-165
- Affiliations：
  
  1.Facultad de Medicina, Universidad Alfonso X, Madrid, Spain
  2.Departamento de Oftalmología, Hospital de Día Pío XII, Madrid, Spain
  3.Servicio de Histología, Departamento, de Investigación, IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain
  4.Departamento de Estructura y Función de Proteínas, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
- Author bio：
  
  *: pedro.cuevas44@gmail.com
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2015-09
- Accepted：
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Dramatic resolution of vitreous hemorrhage after an intravitreal injection of dobesilate[J]. MMR, 2015,2(3):163-165.

Pedro Cuevas, Luis Antonio Outeiriño, Carlos Azanza, et al. Dramatic resolution of vitreous hemorrhage after an intravitreal injection of dobesilate[J]. Military Medical Research, 2015, 2(3): 163-165.
Dramatic resolution of vitreous hemorrhage after an intravitreal injection of dobesilate[J]. MMR, 2015,2(3):163-165. DOI：

Pedro Cuevas, Luis Antonio Outeiriño, Carlos Azanza, et al. Dramatic resolution of vitreous hemorrhage after an intravitreal injection of dobesilate[J]. Military Medical Research, 2015, 2(3): 163-165. DOI：

摘要

Abstract

Vitreous hemorrhages are important clinical manifestations of proliferative diabetic retinopathy. Non-cleared vitreous hemorrhages could lead to hemosiderosis bulbi and glaucoma. Here

we describe the case of a type 2 diabetic patient presenting anterior segment and vitreous hemorrhages that resolved three days after treatment with a single intravitreal injection of dobesilate.

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Goff MJ , McDonald HR , Johnson RN , Ai E , Jumper JM , Fu AD . Causes and treatment of vitreous hemorrhage . Compr Ophthalmol Update . 2006 ; 7 : 97 - 111 .

Spraul CW , Grossniklaus HE . Vitreous Hemorrhage . Surv Ophthalmol . 1997 ; 42 : 3 - 39 .

Aiello, LP , Brucker AJ , Chang S , Cunningham ET Jr , D'Amico DJ , Flynn HW Jr , et al . Evolving guidelines for intravitreous injections . Retina . 2004 ; 24 : S3 - 19 .

Leal EC , Martins J , Voabil P , Liberal J , Chiavaroli C , Bauer J , et al . Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes . Diabetes . 2010 ; 59 : 2637 - 45 .

Lameynardie S , Chiavaroli C , Travo P , Garay RP , Parés-Herbuté N . Inhibition of choroidal angiogenesis by calcium dobesilate in normal Wistar and diabetic GK rats . Eur J Pharmacol . 2005 ; 510 : 149 - 56 .

Fernández IS , Cuevas P , Angulo J , López-Navajas P , Canales-Mayordomo A , González-Corrochano R , et al . Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors . J Biol Chem . 2010 ; 285 : 11714 - 29 .

Thomas KA , Rios-Candelore M , Giménez-Gallego G , DiSalvo J , Bennett C , Rodkey J , et al . Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1 . Proc Natl Acad Sci U S A . 1985 ; 82 : 6409 - 13 .

Thomas KA , Giménez-Gallego G . Fibroblast growth factors: broad spectrum mitogens with potent angiogenic activity . Trends Biochem Sci . 1986 ; 11 : 81 - 4 .

Presta M , Andrés G , Leali D , Dell'Era P , Ronca R . Inflammatory cells and chemokines sustain FGF2-induced angiogenesis . Eur Cytokine Netw . 2009 ; 20 : 39 - 50 .

Andrés G , Leali D , Mitola S , Coltrini D , Camozzi M , Corsini M , et al . A pro-inflammatory signature mediates FGF2-induced angiogenesis . J Cell Mol Med . 2009 ; 13 : 2083 - 108 .

Yum HY , Cho JY , Miller M , Broide DH . Allergen-induced coexpression of bFGF and TGF-β1 by macrophages in a mouse model of airway remodeling: bFGF induces macrophage TGF-β1 expression in vitro . Int Arch Allergy Immunol . 2011 ; 155 : 12 - 22 .

Fredj-Reygrobellet D , Baudouin C , Nègre F , Caruelle JP , Gastaud P , Lapalus P . Acidic FGF and other growth factors in preretinal membranes from patients with diabetic retinopathy and proliferative vitreoretinopathy . Ophthalmic Res . 1991 ; 23 : 154 - 61 .

Simó R , Carrasco E , García-Ramírez M , Hernández C . Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy . Curr Diabetes Rev . 2006 ; 2 : 71 - 98 .

McDonnell K , Bowden ET , Cabal-Manzano R , Hoxter B , Riegel AT , Wellstein A . Vascular leakage in chick embryos after expression of a secreted binding protein for fibroblast growth factors . Lab Invest . 2005 ; 85 : 747 - 55 .

Ribatti D , Gualandris A , Belleri M , Massardi L , Nico B , Rusnati M , et al . Alterations of blood vessel development by endothelial cells overexpressing fibroblast growth factor-2 . J Pathol . 1999 ; 189 : 590 - 9 .

Cha YI , DuBois RN . NSAIDs and cancer prevention: targets downstream of COX-2 . Annu Rev Med . 2007 ; 58 : 239 - 52 .

Jerebtsova M , Wong E , Przygodzki R , Tang P , Ray PE . A novel role of fibroblast growth factor-2 and pentosan polysulfate in the pathogenesis of intestinal bleeding in mice . Am J Physiol Heart Circ Physiol . 2007 ; 292 : H743 - 50 .

Adini I , Ghosh K , Adini A , Chi ZL , Yoshimura T , Benny O , et al . Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment . J Clin Invest . 2014 ; 124 : 425 - 36 .

Cuevas P , Carceller F , Reimers D , Cuevas B , Lozano RM , Giménez-Gallego G . Inhibition of intra-tumoral angiogenesis and glioma growth by the fibroblast growth factor inhibitor 1,3,6-naphthalenetrisulfonate . Neurol Res . 1999 ; 21 : 481 - 7 .

Favre M . Treatment of diabetic retinopathy and recurrent hemorrhages into the vitreous with calcium dobesilate . Ophthalmologica . 1970 ; 161 : 389 - 93 .

Cuevas P , Outeiriño LA , Azanza C , Giménez-Gallego G . Intravitreal dobesilate in the treatment of choroidal neovascularization associated with age-related macular degeneration. Report of two cases . BMJ Case Rep . 2012 ; doi: 10.1136/bcr-2012-006619 http://doi.org/10.1136/bcr-2012-006619 .

Cuevas P , Outeiriño LA , Azanza C , Angulo J , Giménez-Gallego G . Case report: resolution of submacular haemorrhage secondary to exudative age-related macular degeneration after a single intravitreal dobesilate injection . F1000 Res . 2013 ; 2 : 271 .

Hunt RW . Etamsylate for prevention of periventricular haemorrhage . Arch Dis Child Fetal Neonatal Ed . 2005 ; 90 : F3 - 5 .

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