The origin and role of innate lymphoid cells in the lung

Deng-Ming Lai; Qiang Shu; Jie Fan

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The origin and role of innate lymphoid cells in the lung

REVIEW | Updated：2022-12-27

- The origin and role of innate lymphoid cells in the lung
- The origin and role of innate lymphoid cells in the lung
- 解放军医学杂志（英文版） 2016年3卷第4期页码：219-229
- Affiliations：
  
  1. Department of Cardiovascular Surgery,the Children’s Hospital of Zhejiang University School of Medicine
  2. Department of Surgery,University of Pittsburgh School of Medicine
  3. Research and Development,Veterans Affairs Pittsburgh Healthcare System
- Author bio：
- Funds：
  
  supported by the USA National Institutes of Health Grant R01-HL-079669（J.F.）;USA National Institutes of Health Grant R01-HL076179（J.F.）;USA National Institutes of Health Grant R56-HL-123882（J.F.）;USA VA Merit Award 1I01BX002729（J.F.）;the Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents（Q.S.）
- DOI：
  中图分类号： R563
- 纸质出版：2016
- Accepted：
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The origin and role of innate lymphoid cells in the lung[J]. 解放军医学杂志（英文版）, 2016,3(4):219-229.

[1]Deng-Ming Lai,Qiang Shu,Jie Fan.The origin and role of innate lymphoid cells in the lung[J].Military Medical Research,2016,3(04):219-229.
The origin and role of innate lymphoid cells in the lung[J]. 解放军医学杂志（英文版）, 2016,3(4):219-229. DOI：

[1]Deng-Ming Lai,Qiang Shu,Jie Fan.The origin and role of innate lymphoid cells in the lung[J].Military Medical Research,2016,3(04):219-229. DOI：

摘要

Abstract

Innate lymphoid cells（ILCs）

a newly identified member of the lymphoid population

play a critical role in the transition from innate to adaptive immunity in host defense.ILCs are important in mucosal barrier immunity

tissue homeostasis

and immune regulation throughout the body.Significant alterations in ILC responses in lung diseases have been observed and reported.Emerging evidence has shown that ILCs are importantly involved in the pathogenesis and development of a variety of lung diseases

i.e.

helminth infections

allergic airway inflammation

and airway hyper-responsiveness.However

as a tissue-resident cell population

the role of ILCs in the lung remains poorly characterized.In this review

we discuss the role of ILCs in lung diseases

the mechanisms underlying the ILCmediated regulation of immunity

and the therapeutic potential of modulating ILC responses.

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