Artificially designed pathogens – a diagnostic option for future military deployments

Andreas E. Zautner; Wycliffe O. Masanta; Rebecca Hinz; Ralf Matthias Hagen; Hagen Frickmann

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Artificially designed pathogens – a diagnostic option for future military deployments

REVIEW | Updated：2022-12-27

- Artificially designed pathogens – a diagnostic option for future military deployments
- Artificially designed pathogens – a diagnostic option for future military deployments
- MMR 2015年2卷第2期页码：110-115
- Affiliations：
  
  1.Institut für Medizinische Mikrobiologie, Universitätsmedizin Göttingen, Göttingen, Germany
  2.Fachbereich Tropenmedizin am Bernhard-Nocht Institut, Bundeswehrkrankenhaus Hamburg, Germany
  3.Institut für Mikrobiologie, Virologie und Hygiene, Universitätsmedizin Rostock, Rostock, Germany
- Author bio：
  
  *: azautne@gwdg.de
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2015-06
- Accepted：
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Artificially designed pathogens – a diagnostic option for future military deployments[J]. MMR, 2015,2(2):110-115.

Andreas E. Zautner, Wycliffe O. Masanta, Rebecca Hinz, et al. Artificially designed pathogens – a diagnostic option for future military deployments[J]. Military Medical Research, 2015, 2(2): 110-115.
Artificially designed pathogens – a diagnostic option for future military deployments[J]. MMR, 2015,2(2):110-115. DOI：

Andreas E. Zautner, Wycliffe O. Masanta, Rebecca Hinz, et al. Artificially designed pathogens – a diagnostic option for future military deployments[J]. Military Medical Research, 2015, 2(2): 110-115. DOI：

摘要

Abstract

Background:

Diagnostic microbial isolates of bio-safety levels 3 and 4 are difficult to handle in medical field camps under military deployment settings. International transport of such isolates is challenging due to restrictions by the International Air Transport Association. An alternative option might be inactivation and sequencing of the pathogen at the deployment site with subsequent sequence-based revitalization in well-equipped laboratories in the home country for further scientific assessment.

Methods:

A literature review was written based on a PubMed search.

Results:

First described for poliovirus in 2002

de novo synthesis of pathogens based on their sequence information has become a well-established procedure in science. Successful syntheses have been demonstrated for both viruses and prokaryotes. However

the technology is not yet available for routine diagnostic purposes.

Conclusions:

Due to the potential utility of diagnostic sequencing and sequence-based de novo synthesis of pathogens

it seems worthwhile to establish the technology for diagnostic purposes over the intermediate term. This is particularly true for resource-restricted deployment settings

where safe handling of harmful pathogens cannot always be guaranteed.

关键词

Keywords

references

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